{"id":192,"date":"2024-05-31T14:43:47","date_gmt":"2024-05-31T14:43:47","guid":{"rendered":"https:\/\/novaptech.com\/?page_id=192"},"modified":"2025-02-28T12:58:22","modified_gmt":"2025-02-28T12:58:22","slug":"aptamers-vs-antibodies-advantages","status":"publish","type":"page","link":"https:\/\/novaptech.com\/en\/aptamers-vs-antibodies-advantages\/","title":{"rendered":"Aptamers vs Antibodies | Novaptech"},"content":{"rendered":"\t\t
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Aptamers vs antibodies
\nWhat are the differences and advantages ?<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Aptamers and antibodies are two major players that have revolutionized the way we approach analysis, diagnosis, treatment and research.
Aptamers are small molecules composed of DNA or RNA that are engineered in the laboratory to bind highly specifically to a given target, whether proteins, viruses, bacteria, eukaryotic cells, drugs or other chemical compounds.
Antibodies are proteins produced naturally by the immune system in response to the presence of antigens, such as bacteria or viruses.
These proteins have the ability to specifically recognize and neutralize these antigens, making them key players in the body’s immune response.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Discover the potential of aptamers<\/span><\/a> and their advantages in the debate of <\/span>aptamers vs antibodies. Learn about the methods of biomarker analysis<\/a> <\/span>and explore the advanced research conducted in our biotechnology laboratory<\/a><\/span> and the innovative approaches to biomarker <\/a>analysis.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Aptamers vs antibodies<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Key advantages of aptamers over antibodies<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u00a0Aptamers are synthetic molecules that can be raised against any kind of target, including toxic or non-immunogenic ones. They bind their target with affinity similar or higher than antibodies. They are 10 fold smaller than antibodies and can be chemically-modified at will in a defined and precise way. They can be easily stored and delivered ; they can be reversibly heat-denatured and renatured. The sourcing is guaranteed with a total batch to batch reproducibility.<\/p>

They can be used under non physiological conditions for analytical purposes. They are non\u2013immunogenic and can be used in vivo<\/em>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\"Aptamers<\/figure><\/div>\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tNovaptech's aptamer services<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Advantages of Aptamers : in short<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Any target<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Tissue penetration<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Superior affinity & specificity<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Scalable production<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Aptamers vs antibodies : in details<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span><\/th>\n\t\t\t \t\t\t\t \n\t\t\t\t\t\t\t\t\t\t\t\t\t\tMonoclonal antibody<\/span><\/th>\n\t\t\t \t\t\t\t \n\t\t\t\t\t\t\t\t\t\t\t\t\t\tAptamer<\/span><\/th>\n\t\t\t \t\t\t\t <\/tr>\n\t\t\t <\/thead>\n\t\t\t \t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\tStability\t\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t \t\t\t\t\t\t\t\t\t\t\t
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Sensitive to temperature, antibodies require refrigeration. The denaturation is irreversible<\/p>\t\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t \t\t\t\t\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\tStable at room temperature, aptamers have longer shelf life. The denaturation is reversible\t\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/tr>\n\t\t\t \t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\tSize\t\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t \t\t\t\t\t\t\t\t\t\t\t
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Large molecules (\u223c 160 kDa), resist to filtration by the kidneys<\/p>\t\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t \t\t\t\t\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\tSmall molecules (10-20 kDa) that display better access to their target\t\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/tr>\n\t\t\t \t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\tDevelopment process\t\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t \t\t\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\tRequire immune response and animals\t\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t \t\t\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\tSelected in vitro by a method that might include positive and negative selection steps, thus ensuring very high specificity. Only a few nanomoles are a few nanomoles of target are required for selection. A large molecular diversity is screened\t\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/tr>\n\t\t\t \t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\tTarget potential\t\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t \t\t\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\tTargets must produce an immune response\t\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t \t\t\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\tCan bind to very small, non-immunogenic, toxic targets\t\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/tr>\n\t\t\t \t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\tProduction time and cost\t\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t \t\t\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\tIn several months \/ The production of antibodies requires long and expensive in vivo procedures\t\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t \t\t\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\tIn several weeks \/ The selected aptamers are chemically synthetized, reducing the production cost\t\t\t\t\t\t\t\t\t\t\t\t<\/div><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/td>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/tr>\n\t\t\t \t\t\t <\/tbody>\n\t\t\t<\/table>\n\t\t<\/div>\n\t \t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Any question ? Contact us<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Any question about selection service or assay development ? Please fill in the form below with relevant details for helping us providing an informative answer. Telephone or video call can be arranged. NDA can be signed, would you wish so. We will answer you as quickly as possible (generally less than 2 working days).<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"Biomarker\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Your scientific contact :<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Jean-Jacques Toulm\u00e9, PhD, CSO<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tThe importance of aptamers and antibodies in diagnostics and analytical applications<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

Aptamers and antibodies play a central role in diagnostics and analytical assays. Their high binding specificities make them tools of choice for quantitatively detecting molecular targets in various samples (tissue, blood, water, food,\u2026). They are widely used for biosensing in association with different modalities of signal transduction (fluorescence, colorimetry, electrochemistry). They enable the quantitative specific detection of the target molecule in the field through simple, cheap and rapid assays.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tThe importance of aptamers and antibodies in research and medicine<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

Aptamers and antibodies play a central role in biomedical research and medical practice. Their high binding specificities make them tools of choice for detecting and identifying specific molecular targets in biological samples.They are widely used in diagnostic tests, biomarker discovery, protein characterization and understanding the mechanisms underlying disease.
In medicine, monoclonal antibodies are used to treat certain autoimmune diseases and certain types of cancer. Aptamers, on the other hand, offer a promising alternative, notably as vectors for targeted drugs and personalized medicine.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

\n\t\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tSpecific features of aptamers<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

The aptamer selection process, or SELEX, lies at the heart of the identification of specific aptamers. It begins with the synthesis of a random oligonucleotide library in which each sequence has a unique three-dimensional structure. This library is then subjected to selection cycles that include binding to the target, washing to remove unbound sequences and recovery of target-bound aptamers. This process is repeated many times until aptamers with high specificity and affinity for the target are selected.<\/p>

Specific binding mechanism<\/strong><\/p>

Aptamers form hydrogen bonds, electrostatic interactions and Van der Waals interactions with the target. This enables highly specific binding between the aptamer and its target, depending on the latter’s precise molecular characteristics. The three-dimensional conformation of the aptamer is crucial, enabling it to adapt perfectly to the shape of the target, thus providing the specificity of the binding.<\/p>

Applications in research and medicine<\/strong><\/p>

The ability of aptamers to bind specifically to molecular targets makes them valuable tools for biomarker detection, protein characterization, drug and contaminant analysis and the understanding of biological mechanisms. They are also used to specifically target tumor cells or virus-infected cells, paving the way for targeted treatment possibilities. In research, aptamers are used to study protein interactions, identify binding partners and explore cell signaling networks<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

\n\t\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t Why choose aptamers over antibodies ?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

One of the major advantages of aptamers over antibodies is their high specificity. Aptamers are identified in the laboratory through positive and negative screening in order to discriminate between closely related targets.
The SELEX selection process generates aptamers that bind tightly and specifically to the target, minimizing non-specific binding to other molecules in the sample. This specificity guarantees greater precision in the detection and quantification of molecular targets, and reduces the risk of false positives and false negatives.
\u00b7 <\/span><\/span>Versatility of aptamers : Aptamers are obtained by chemical synthesis on solid support. Chemical modifications can be introduced at will at given sites in order to provide them with additional properties depending on the application (increased lifetime, detection by fluorescence, immobilization on a biochip, \u2026).
\u00b7 <\/span><\/span>Thermal stability of aptamers : Heating aptamer solution to 80-90 \u00b0C will denature them.
However, unlike proteins, they will refold upon cooling and regain their functionality.<\/p>\n

Cost advantage for aptamers<\/strong><\/p>\n

The large-scale production of monoclonal antibodies requires the development and maintenance of hybrid cell lines, which is extremely costly. What’s more, antibody production <\/span>requires specialized facilities and thus a major investment in material resources.<\/span><\/p>\n

In contrast, in terms of production costs, aptamers offer a significant advantage over antibodies. Morever the chemical synthesis of aptamers, including under GMP conditions, ensures a guaranteed sourcing, no batch no batch variability.<\/p>\n

Our partnership with Eurogentec<\/strong><\/p>\n

Eurogentec provides oligonucleotide products and services to scientists involved in life science research, molecular diagnostics and therapeutic development. An expert in both small- and large-scale synthesis, Eurogentec produces a wide range of customized oligonucleotides, including chemically-modified ones (nuclease resistant backbones, modified nucleic acid bases, end-conjugated sequences).
Novaptech and Eurogentec have signed a partnership agreement for the production of aptamers selected by Novaptech. https:\/\/www.eurogentec.com\/en\/search?q=novaptech<\/a><\/p>\n

Low\/no immunogenicity of aptamers<\/strong><\/p>\n

Another major advantage in the antibody vs aptamer match-up lies in the low or even absence of immunogenicity of aptamers compared with antibodies.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Aptamers vs antibodies What are the differences and advantages ? Aptamers and antibodies are two major players that have revolutionized the way we approach analysis, diagnosis, treatment and research.Aptamers are small molecules composed of DNA or RNA that are engineered in the laboratory to bind highly specifically to a given target, whether proteins, viruses, bacteria, eukaryotic cells, drugs or other chemical compounds.Antibodies are proteins produced naturally by the immune system in response to the presence of antigens, such as bacteria or viruses.These proteins have the ability to specifically recognize and neutralize these antigens, making them key players in the body’s immune response. Discover the potential of aptamers and their advantages in the debate of aptamers vs antibodies. Learn about the methods of biomarker analysis and explore the advanced research conducted in our biotechnology laboratory and the innovative approaches to biomarker analysis. Aptamers vs antibodies Key advantages of aptamers over antibodies \u00a0Aptamers are synthetic molecules that can be raised against any kind of target, including toxic or non-immunogenic ones. They bind their target with affinity similar or higher than antibodies. They are 10 fold smaller than antibodies and can be chemically-modified at will in a defined and precise way. They can be easily stored and delivered ; they can be reversibly heat-denatured and renatured. The sourcing is guaranteed with a total batch to batch reproducibility. They can be used under non physiological conditions for analytical purposes. They are non\u2013immunogenic and can be used in vivo. Novaptech’s aptamer services Advantages of Aptamers : in short Any target Tissue penetration Superior affinity & specificity Scalable production Aptamers vs antibodies : in details Monoclonal antibody Aptamer Stability Sensitive to temperature, antibodies require refrigeration. The denaturation is irreversible Stable at room temperature, aptamers have longer shelf life. The denaturation is reversible Size Large molecules (\u223c 160 kDa), resist to filtration by the kidneys Small molecules (10-20 kDa) that display better access to their target Development process Require immune response and animals Selected in vitro by a method that might include positive and negative selection steps, thus ensuring very high specificity. Only a few nanomoles are a few nanomoles of target are required for selection. A large molecular diversity is screened Target potential Targets must produce an immune response Can bind to very small, non-immunogenic, toxic targets Production time and cost In several months \/ The production of antibodies requires long and expensive in vivo procedures In several weeks \/ The selected aptamers are chemically synthetized, reducing the production cost Any question ? Contact us Any question about selection service or assay development ? Please fill in the form below with relevant details for helping us providing an informative answer. Telephone or video call can be arranged. NDA can be signed, would you wish so. We will answer you as quickly as possible (generally less than 2 working days). Contact us Your scientific contact : Jean-Jacques Toulm\u00e9, PhD, CSO The importance of aptamers and antibodies in diagnostics and analytical applications Aptamers and antibodies play a central role in diagnostics and analytical assays. Their high binding specificities make them tools of choice for quantitatively detecting molecular targets in various samples (tissue, blood, water, food,\u2026). They are widely used for biosensing in association with different modalities of signal transduction (fluorescence, colorimetry, electrochemistry). They enable the quantitative specific detection of the target molecule in the field through simple, cheap and rapid assays. The importance of aptamers and antibodies in research and medicine Aptamers and antibodies play a central role in biomedical research and medical practice. Their high binding specificities make them tools of choice for detecting and identifying specific molecular targets in biological samples.They are widely used in diagnostic tests, biomarker discovery, protein characterization and understanding the mechanisms underlying disease. In medicine, monoclonal antibodies are used to treat certain autoimmune diseases and certain types of cancer. Aptamers, on the other hand, offer a promising alternative, notably as vectors for targeted drugs and personalized medicine. Specific features of aptamers The aptamer selection process, or SELEX, lies at the heart of the identification of specific aptamers. It begins with the synthesis of a random oligonucleotide library in which each sequence has a unique three-dimensional structure. This library is then subjected to selection cycles that include binding to the target, washing to remove unbound sequences and recovery of target-bound aptamers. This process is repeated many times until aptamers with high specificity and affinity for the target are selected. Specific binding mechanism Aptamers form hydrogen bonds, electrostatic interactions and Van der Waals interactions with the target. This enables highly specific binding between the aptamer and its target, depending on the latter’s precise molecular characteristics. The three-dimensional conformation of the aptamer is crucial, enabling it to adapt perfectly to the shape of the target, thus providing the specificity of the binding. Applications in research and medicine The ability of aptamers to bind specifically to molecular targets makes them valuable tools for biomarker detection, protein characterization, drug and contaminant analysis and the understanding of biological mechanisms. They are also used to specifically target tumor cells or virus-infected cells, paving the way for targeted treatment possibilities. In research, aptamers are used to study protein interactions, identify binding partners and explore cell signaling networks Why choose aptamers over antibodies ? One of the major advantages of aptamers over antibodies is their high specificity. Aptamers are identified in the laboratory through positive and negative screening in order to discriminate between closely related targets. The SELEX selection process generates aptamers that bind tightly and specifically to the target, minimizing non-specific binding to other molecules in the sample. This specificity guarantees greater precision in the detection and quantification of molecular targets, and reduces the risk of false positives and false negatives. \u00b7 Versatility of aptamers : Aptamers are obtained by chemical synthesis on solid support. Chemical modifications can be introduced at will at given sites in order to provide them with additional properties depending on the application (increased lifetime, detection by fluorescence, immobilization on a biochip, \u2026). \u00b7 Thermal stability of<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-192","page","type-page","status-publish","hentry"],"yoast_head":"\nAptamers vs Antibodies | Novaptech - Novaptech<\/title>\n<meta name=\"description\" content=\"Aptamers and antibodies are two major players that have revolutionized the way we approach analysis, diagnosis, treatment and research.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/novaptech.com\/en\/aptamers-vs-antibodies-advantages\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Aptamers vs Antibodies | Novaptech - 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