{"id":326,"date":"2024-06-01T12:49:24","date_gmt":"2024-06-01T12:49:24","guid":{"rendered":"https:\/\/novaptech.com\/?page_id=326"},"modified":"2025-05-12T11:48:48","modified_gmt":"2025-05-12T11:48:48","slug":"second-generation-aptamers-selkiss-aptaswitch","status":"publish","type":"page","link":"https:\/\/novaptech.com\/en\/second-generation-aptamers-selkiss-aptaswitch\/","title":{"rendered":"Novaptech structure switching aptamers"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"326\" class=\"elementor elementor-326\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7dc87abd e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"7dc87abd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-206a8c99 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"206a8c99\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2b7a0202 elementor-widget elementor-widget-heading\" data-id=\"2b7a0202\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Structure-switching aptamers<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4dcbbe0d elementor-widget elementor-widget-heading\" data-id=\"4dcbbe0d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Aptaswich<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-24b16c4d elementor-widget elementor-widget-heading\" data-id=\"24b16c4d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Aptamers are known to generally undergo a conformational change upon binding to their ligand. This can be exploited for their selection and for signaling the presence of the target. The structural change is then associated to a signal (fluorescence energy transfer for instance). This can be deliberately exploited for the design of aptamer-based biosensors.<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6d856f8 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"6d856f8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/novaptech.com\/contact-us-aptamer-company-france-eu\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Tell us about your assay<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-660eac06 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"660eac06\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5fa2a741 elementor-widget elementor-widget-image\" data-id=\"5fa2a741\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto.jpg\" class=\"attachment-large size-large wp-image-331\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto.jpg 600w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-300x200.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-89e1256 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"89e1256\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-11e51a9 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"11e51a9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ec6579a elementor-widget elementor-widget-image\" data-id=\"ec6579a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-1.jpg\" class=\"attachment-large size-large wp-image-341\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-1.jpg 600w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-1-300x200.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7aa026f e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"7aa026f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4e52eaf elementor-widget elementor-widget-heading\" data-id=\"4e52eaf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The NOVAswitch technology<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76549eb elementor-widget elementor-widget-heading\" data-id=\"76549eb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">The selection is carried out against free molecules in solution whereas the oligonucleotide library is immobilized in a support. Candidates released in the solution following the addition of the target molecule  are collected, amplified and analyzed. In another format the selection takes advantage of so-called kissing interactions. In this case, the addition of the target promotes the interaction of candidates to a hairpin oligonucleotide that are subsequently collected, amplified and analyzed. The selected candidates are functional aptaswitch. They can be integrated into biosensors with different modalities of signal transduction.<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-235fc27 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"235fc27\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2b2af0e e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"2b2af0e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0014846 elementor-widget elementor-widget-heading\" data-id=\"0014846\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Examples of application<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1526f10 elementor-widget elementor-widget-text-editor\" data-id=\"1526f10\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div><span style=\"color: #808080;\"><span lang=\"EN-US\">Durand, G., Lisi, S., Ravelet, C., Dausse, E., Peyrin, E., &amp; Toulm\u00e9, J.-J. (2014). <b><span style=\"color: #808080;\"><a style=\"color: #808080;\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201400402\" target=\"_blank\" rel=\"noopener\">Riboswitches Based on Kissing Complexes for the Detection of Small Ligands.<\/a><\/span>\u00a0<\/b><\/span><i style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var( --e-global-typography-text-font-size ); text-align: var(--text-align);\">Angewandte Chemie International Edition<\/i><span style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var( --e-global-typography-text-font-size ); text-align: var(--text-align);\">, 53(24), 6105\u20136110.<\/span><\/span><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ba97f0 elementor-widget elementor-widget-text-editor\" data-id=\"9ba97f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400;\"><span style=\"color: #808080;\">Durand, G., Dausse, E., Goux, E., Fiore, E., Peyrin, E., Ravelet, C., &amp; Toulm\u00e9, J.-J. (2016). <a style=\"color: #808080;\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4872101\/\" target=\"_blank\" rel=\"noopener\"><strong>A combinatorial approach to the repertoire of RNA kissing motifs; towards multiplex detection by switching hairpin aptamers.<\/strong><\/a> <em>Nucleic Acids Research<\/em>, 44(9), 4450-4459.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fd6b369 elementor-widget elementor-widget-text-editor\" data-id=\"fd6b369\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400;\"><span style=\"color: #808080;\">Goux, E., Dausse, E., Guieu, V., Az\u00e9ma, L., Durand, G., Henry, M., Choisnard, L., Toulm\u00e9, J.-J., Raveleta, C., &amp; Peyrin, E. (2017). <a style=\"color: #808080;\" href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2017\/nr\/c7nr00612h\" target=\"_blank\" rel=\"noopener\"><strong>A colorimetric nanosensor based on a selective target-responsive aptamer kissing complex<\/strong>.<\/a> <em>Nanoscale<\/em>, Issue 12.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-245d624 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"245d624\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/novaptech.com\/rapid-field-tests-pollutants-drug-residues\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Learn about our R&amp;D program for rapid &amp; multiplex testing<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-17147e6 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"17147e6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e89e81b elementor-widget elementor-widget-image\" data-id=\"e89e81b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"600\" height=\"322\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto.png\" class=\"attachment-large size-large wp-image-348\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto.png 600w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-300x161.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-97654c5 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"97654c5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f88d537 elementor-widget elementor-widget-heading\" data-id=\"f88d537\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Aptaswitch-based assays<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1d8dc6b4 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"1d8dc6b4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-35058b91 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"35058b91\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-eafd2ac elementor-widget elementor-widget-video\" data-id=\"eafd2ac\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;vimeo&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/novaptech-com.preview-domain.com\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/thumb_348_196_0_0_crop.png&quot;,&quot;id&quot;:294,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;&quot;,&quot;source&quot;:&quot;library&quot;}}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<iframe class=\"elementor-video-iframe\" allowfullscreen allow=\"clipboard-write\" title=\"Lecteur vid\u00e9o vimeo\" src=\"https:\/\/player.vimeo.com\/video\/267761524?color&amp;autopause=0&amp;loop=0&amp;muted=0&amp;title=1&amp;portrait=1&amp;byline=1#t=\"><\/iframe>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop.png);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Lire la vid\u00e9o\" tabindex=\"0\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-eicon-play\" viewBox=\"0 0 1000 1000\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M838 162C746 71 633 25 500 25 371 25 258 71 163 162 71 254 25 367 25 500 25 633 71 746 163 837 254 929 367 979 500 979 633 979 746 933 838 837 929 746 975 633 975 500 975 367 929 254 838 162M808 192C892 279 933 379 933 500 933 621 892 725 808 808 725 892 621 938 500 938 379 938 279 896 196 808 113 725 67 621 67 500 67 379 108 279 196 192 279 108 383 62 500 62 621 62 721 108 808 192M438 392V642L642 517 438 392Z\"><\/path><\/svg>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4569d06a elementor-widget elementor-widget-heading\" data-id=\"4569d06a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Rapid tests<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6f4959df e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"6f4959df\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2b0acb2f elementor-widget elementor-widget-image\" data-id=\"2b0acb2f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"348\" height=\"196\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-6.jpg\" class=\"attachment-large size-large wp-image-363\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-6.jpg 348w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-6-300x169.jpg 300w\" sizes=\"(max-width: 348px) 100vw, 348px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a04dbc8 elementor-widget elementor-widget-heading\" data-id=\"1a04dbc8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Aptamer lateral flow assays <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7a258799 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"7a258799\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-257faeb3 elementor-widget elementor-widget-image\" data-id=\"257faeb3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"348\" height=\"196\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-1-1.jpg\" class=\"attachment-large size-large wp-image-361\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-1-1.jpg 348w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-1-1-300x169.jpg 300w\" sizes=\"(max-width: 348px) 100vw, 348px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2eded7cf elementor-widget elementor-widget-heading\" data-id=\"2eded7cf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Environment &amp; food safety monitoring\n<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f60eb25 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"f60eb25\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-41e1fce elementor-widget elementor-widget-image\" data-id=\"41e1fce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"348\" height=\"196\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-2.jpg\" class=\"attachment-large size-large wp-image-362\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-2.jpg 348w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-2-300x169.jpg 300w\" sizes=\"(max-width: 348px) 100vw, 348px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-932b5e4 elementor-widget elementor-widget-heading\" data-id=\"932b5e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Detection of a drug in biological fluids\n<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3a623ed e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"3a623ed\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d8cd2c8 elementor-widget elementor-widget-heading\" data-id=\"d8cd2c8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">They support our R&amp;D<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b580d6e e-grid e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"b580d6e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-89eff04 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"89eff04\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d2ddd3d elementor-widget elementor-widget-image\" data-id=\"d2ddd3d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"500\" height=\"500\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-region-nouvelle-aquitaine.jpg\" class=\"attachment-large size-large wp-image-125\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-region-nouvelle-aquitaine.jpg 500w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-region-nouvelle-aquitaine-300x300.jpg 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-region-nouvelle-aquitaine-150x150.jpg 150w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-56d77c1 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"56d77c1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e17ceac elementor-widget elementor-widget-image\" data-id=\"e17ceac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"256\" height=\"110\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/Allis-NA.png\" class=\"attachment-large size-large wp-image-3300\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/Allis-NA.png 256w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/Allis-NA-18x8.png 18w\" sizes=\"(max-width: 256px) 100vw, 256px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0cf75b3 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"0cf75b3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4f51eff elementor-widget elementor-widget-image\" data-id=\"4f51eff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"343\" height=\"110\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/Mabdesign.png\" class=\"attachment-large size-large wp-image-3302\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/Mabdesign.png 343w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/Mabdesign-300x96.png 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/Mabdesign-18x6.png 18w\" sizes=\"(max-width: 343px) 100vw, 343px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f59177 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"7f59177\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4972851 elementor-widget elementor-widget-image\" data-id=\"4972851\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"177\" height=\"172\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/France-2030.png\" class=\"attachment-large size-large wp-image-3301\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/France-2030.png 177w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/France-2030-12x12.png 12w\" sizes=\"(max-width: 177px) 100vw, 177px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2671812 elementor-widget elementor-widget-image\" data-id=\"2671812\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"500\" height=\"500\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-bpi-france.jpg\" class=\"attachment-large size-large wp-image-123\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-bpi-france.jpg 500w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-bpi-france-300x300.jpg 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-bpi-france-150x150.jpg 150w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c8edfc0 elementor-widget elementor-widget-image\" data-id=\"c8edfc0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-aquiti.jpg\" class=\"attachment-large size-large wp-image-122\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-aquiti.jpg 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-aquiti-150x150.jpg 150w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c7a1ae8 elementor-widget elementor-widget-image\" data-id=\"c7a1ae8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-unitec.png\" class=\"attachment-large size-large wp-image-126\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-unitec.png 1000w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-unitec-300x300.png 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-unitec-150x150.png 150w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-partners-unitec-768x768.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5e9e7e0 elementor-widget elementor-widget-image\" data-id=\"5e9e7e0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"284\" height=\"177\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/ADI.jpeg\" class=\"attachment-large size-large wp-image-3685\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/ADI.jpeg 284w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/ADI-18x12.jpeg 18w\" sizes=\"(max-width: 284px) 100vw, 284px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9dd70c5 elementor-widget elementor-widget-image\" data-id=\"9dd70c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"530\" height=\"95\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/fundmeup.jpeg\" class=\"attachment-large size-large wp-image-3684\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/fundmeup.jpeg 530w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/fundmeup-300x54.jpeg 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/fundmeup-18x3.jpeg 18w\" sizes=\"(max-width: 530px) 100vw, 530px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e980cd5 elementor-widget elementor-widget-image\" data-id=\"e980cd5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"230\" height=\"163\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-europe-japon.png\" class=\"attachment-large size-large wp-image-121\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d6a1b1 elementor-widget elementor-widget-image\" data-id=\"0d6a1b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"171\" height=\"171\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/IECB.jpg\" class=\"attachment-large size-large wp-image-1312\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/IECB.jpg 171w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/IECB-150x150.jpg 150w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/IECB-12x12.jpg 12w\" sizes=\"(max-width: 171px) 100vw, 171px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1866707 elementor-widget elementor-widget-image\" data-id=\"1866707\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"163\" height=\"123\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/novaptech-europe.png\" class=\"attachment-large size-large wp-image-120\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9a65761 elementor-widget elementor-widget-image\" data-id=\"9a65761\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"500\" height=\"500\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/07\/Design-sans-titre-34.png\" class=\"attachment-full size-full wp-image-2092\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/07\/Design-sans-titre-34.png 500w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/07\/Design-sans-titre-34-300x300.png 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/07\/Design-sans-titre-34-150x150.png 150w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/07\/Design-sans-titre-34-12x12.png 12w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-66226de elementor-widget elementor-widget-image\" data-id=\"66226de\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"200\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/07\/1280px-Inserm.svg_-1024x256.png\" class=\"attachment-large size-large wp-image-2090\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/07\/1280px-Inserm.svg_-1024x256.png 1024w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/07\/1280px-Inserm.svg_-300x75.png 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/07\/1280px-Inserm.svg_-768x192.png 768w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/07\/1280px-Inserm.svg_-18x5.png 18w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/07\/1280px-Inserm.svg_.png 1280w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-21d9c7b elementor-widget elementor-widget-image\" data-id=\"21d9c7b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"293\" height=\"221\" 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We will answer you as quickly as possible (generally less than 2 working days).<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5e485a93 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"5e485a93\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-627820c0 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"627820c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/novaptech.com\/contact-us-aptamer-company-france-eu\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contact us<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-378f4617 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"378f4617\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-71b14de6 elementor-widget elementor-widget-image\" data-id=\"71b14de6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"337\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/thumb_600_0_0_0_auto-2.jpg\" class=\"attachment-full size-full wp-image-183\" alt=\"Biomarker analysis\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/thumb_600_0_0_0_auto-2.jpg 600w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/thumb_600_0_0_0_auto-2-300x169.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-380fef0f elementor-widget elementor-widget-heading\" data-id=\"380fef0f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Your scientific contact :<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-18eee01e elementor-widget elementor-widget-heading\" data-id=\"18eee01e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Jean-Jacques Toulm\u00e9, PhD, CSO<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Structure-switching aptamers Aptaswich Aptamers are known to generally undergo a conformational change upon binding to their ligand. This can be exploited for their selection and for signaling the presence of the target. The structural change is then associated to a signal (fluorescence energy transfer for instance). This can be deliberately exploited for the design of aptamer-based biosensors. Tell us about your assay The NOVAswitch technology The selection is carried out against free molecules in solution whereas the oligonucleotide library is immobilized in a support. Candidates released in the solution following the addition of the target molecule are collected, amplified and analyzed. In another format the selection takes advantage of so-called kissing interactions. In this case, the addition of the target promotes the interaction of candidates to a hairpin oligonucleotide that are subsequently collected, amplified and analyzed. The selected candidates are functional aptaswitch. They can be integrated into biosensors with different modalities of signal transduction. Examples of application Durand, G., Lisi, S., Ravelet, C., Dausse, E., Peyrin, E., &amp; Toulm\u00e9, J.-J. (2014). Riboswitches Based on Kissing Complexes for the Detection of Small Ligands.\u00a0Angewandte Chemie International Edition, 53(24), 6105\u20136110. Durand, G., Dausse, E., Goux, E., Fiore, E., Peyrin, E., Ravelet, C., &amp; Toulm\u00e9, J.-J. (2016). A combinatorial approach to the repertoire of RNA kissing motifs; towards multiplex detection by switching hairpin aptamers. Nucleic Acids Research, 44(9), 4450-4459. Goux, E., Dausse, E., Guieu, V., Az\u00e9ma, L., Durand, G., Henry, M., Choisnard, L., Toulm\u00e9, J.-J., Raveleta, C., &amp; Peyrin, E. (2017). A colorimetric nanosensor based on a selective target-responsive aptamer kissing complex. Nanoscale, Issue 12. Learn about our R&#038;D program for rapid &#038; multiplex testing Aptaswitch-based assays Rapid tests Aptamer lateral flow assays Environment &amp; food safety monitoring Detection of a drug in biological fluids They support our R&amp;D Any question ? Just ask us ! Any question about selection service or assay development ? Please fill in the form below with relevant details for helping us providing an informative answer. Telephone or video call can be arranged. NDA can be signed, would you wish so. We will answer you as quickly as possible (generally less than 2 working days). Contact us Your scientific contact : Jean-Jacques Toulm\u00e9, PhD, CSO<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-326","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Novaptech structure switching aptamers - Novaptech<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/novaptech.com\/en\/second-generation-aptamers-selkiss-aptaswitch\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Novaptech structure switching aptamers - Novaptech\" \/>\n<meta property=\"og:description\" content=\"Structure-switching aptamers Aptaswich Aptamers are known to generally undergo a conformational change upon binding to their ligand. This can be exploited for their selection and for signaling the presence of the target. The structural change is then associated to a signal (fluorescence energy transfer for instance). This can be deliberately exploited for the design of aptamer-based biosensors. Tell us about your assay The NOVAswitch technology The selection is carried out against free molecules in solution whereas the oligonucleotide library is immobilized in a support. Candidates released in the solution following the addition of the target molecule are collected, amplified and analyzed. In another format the selection takes advantage of so-called kissing interactions. In this case, the addition of the target promotes the interaction of candidates to a hairpin oligonucleotide that are subsequently collected, amplified and analyzed. The selected candidates are functional aptaswitch. They can be integrated into biosensors with different modalities of signal transduction. Examples of application Durand, G., Lisi, S., Ravelet, C., Dausse, E., Peyrin, E., &amp; Toulm\u00e9, J.-J. (2014). Riboswitches Based on Kissing Complexes for the Detection of Small Ligands.\u00a0Angewandte Chemie International Edition, 53(24), 6105\u20136110. Durand, G., Dausse, E., Goux, E., Fiore, E., Peyrin, E., Ravelet, C., &amp; Toulm\u00e9, J.-J. (2016). A combinatorial approach to the repertoire of RNA kissing motifs; towards multiplex detection by switching hairpin aptamers. Nucleic Acids Research, 44(9), 4450-4459. Goux, E., Dausse, E., Guieu, V., Az\u00e9ma, L., Durand, G., Henry, M., Choisnard, L., Toulm\u00e9, J.-J., Raveleta, C., &amp; Peyrin, E. (2017). A colorimetric nanosensor based on a selective target-responsive aptamer kissing complex. Nanoscale, Issue 12. Learn about our R&#038;D program for rapid &#038; multiplex testing Aptaswitch-based assays Rapid tests Aptamer lateral flow assays Environment &amp; food safety monitoring Detection of a drug in biological fluids They support our R&amp;D Any question ? Just ask us ! Any question about selection service or assay development ? Please fill in the form below with relevant details for helping us providing an informative answer. Telephone or video call can be arranged. NDA can be signed, would you wish so. We will answer you as quickly as possible (generally less than 2 working days). Contact us Your scientific contact : Jean-Jacques Toulm\u00e9, PhD, CSO\" \/>\n<meta property=\"og:url\" content=\"https:\/\/novaptech.com\/en\/second-generation-aptamers-selkiss-aptaswitch\/\" \/>\n<meta property=\"og:site_name\" content=\"Novaptech\" \/>\n<meta property=\"article:modified_time\" content=\"2025-05-12T11:48:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/\",\"url\":\"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/\",\"name\":\"Novaptech structure switching aptamers - Novaptech\",\"isPartOf\":{\"@id\":\"https:\/\/novaptech.com\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto.jpg\",\"datePublished\":\"2024-06-01T12:49:24+00:00\",\"dateModified\":\"2025-05-12T11:48:48+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/#primaryimage\",\"url\":\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto.jpg\",\"contentUrl\":\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/novaptech.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Novaptech structure switching aptamers\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/novaptech.com\/en\/#website\",\"url\":\"https:\/\/novaptech.com\/en\/\",\"name\":\"Novaptech\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/novaptech.com\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/novaptech.com\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/novaptech.com\/en\/#organization\",\"name\":\"Novaptech\",\"url\":\"https:\/\/novaptech.com\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/novaptech.com\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/cropped-LOGO.png\",\"contentUrl\":\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/cropped-LOGO.png\",\"width\":335,\"height\":140,\"caption\":\"Novaptech\"},\"image\":{\"@id\":\"https:\/\/novaptech.com\/en\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Novaptech structure switching aptamers - Novaptech","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/novaptech.com\/en\/second-generation-aptamers-selkiss-aptaswitch\/","og_locale":"en_US","og_type":"article","og_title":"Novaptech structure switching aptamers - Novaptech","og_description":"Structure-switching aptamers Aptaswich Aptamers are known to generally undergo a conformational change upon binding to their ligand. This can be exploited for their selection and for signaling the presence of the target. The structural change is then associated to a signal (fluorescence energy transfer for instance). This can be deliberately exploited for the design of aptamer-based biosensors. Tell us about your assay The NOVAswitch technology The selection is carried out against free molecules in solution whereas the oligonucleotide library is immobilized in a support. Candidates released in the solution following the addition of the target molecule are collected, amplified and analyzed. In another format the selection takes advantage of so-called kissing interactions. In this case, the addition of the target promotes the interaction of candidates to a hairpin oligonucleotide that are subsequently collected, amplified and analyzed. The selected candidates are functional aptaswitch. They can be integrated into biosensors with different modalities of signal transduction. Examples of application Durand, G., Lisi, S., Ravelet, C., Dausse, E., Peyrin, E., &amp; Toulm\u00e9, J.-J. (2014). Riboswitches Based on Kissing Complexes for the Detection of Small Ligands.\u00a0Angewandte Chemie International Edition, 53(24), 6105\u20136110. Durand, G., Dausse, E., Goux, E., Fiore, E., Peyrin, E., Ravelet, C., &amp; Toulm\u00e9, J.-J. (2016). A combinatorial approach to the repertoire of RNA kissing motifs; towards multiplex detection by switching hairpin aptamers. Nucleic Acids Research, 44(9), 4450-4459. Goux, E., Dausse, E., Guieu, V., Az\u00e9ma, L., Durand, G., Henry, M., Choisnard, L., Toulm\u00e9, J.-J., Raveleta, C., &amp; Peyrin, E. (2017). A colorimetric nanosensor based on a selective target-responsive aptamer kissing complex. Nanoscale, Issue 12. Learn about our R&#038;D program for rapid &#038; multiplex testing Aptaswitch-based assays Rapid tests Aptamer lateral flow assays Environment &amp; food safety monitoring Detection of a drug in biological fluids They support our R&amp;D Any question ? Just ask us ! Any question about selection service or assay development ? Please fill in the form below with relevant details for helping us providing an informative answer. Telephone or video call can be arranged. NDA can be signed, would you wish so. We will answer you as quickly as possible (generally less than 2 working days). Contact us Your scientific contact : Jean-Jacques Toulm\u00e9, PhD, CSO","og_url":"https:\/\/novaptech.com\/en\/second-generation-aptamers-selkiss-aptaswitch\/","og_site_name":"Novaptech","article_modified_time":"2025-05-12T11:48:48+00:00","og_image":[{"url":"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/","url":"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/","name":"Novaptech structure switching aptamers - Novaptech","isPartOf":{"@id":"https:\/\/novaptech.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/#primaryimage"},"image":{"@id":"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/#primaryimage"},"thumbnailUrl":"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto.jpg","datePublished":"2024-06-01T12:49:24+00:00","dateModified":"2025-05-12T11:48:48+00:00","breadcrumb":{"@id":"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/#primaryimage","url":"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto.jpg","contentUrl":"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/novaptech.com\/en\/"},{"@type":"ListItem","position":2,"name":"Novaptech structure switching aptamers"}]},{"@type":"WebSite","@id":"https:\/\/novaptech.com\/en\/#website","url":"https:\/\/novaptech.com\/en\/","name":"Novaptech","description":"","publisher":{"@id":"https:\/\/novaptech.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/novaptech.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/novaptech.com\/en\/#organization","name":"Novaptech","url":"https:\/\/novaptech.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/novaptech.com\/en\/#\/schema\/logo\/image\/","url":"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/cropped-LOGO.png","contentUrl":"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/cropped-LOGO.png","width":335,"height":140,"caption":"Novaptech"},"image":{"@id":"https:\/\/novaptech.com\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/pages\/326","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/comments?post=326"}],"version-history":[{"count":114,"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/pages\/326\/revisions"}],"predecessor-version":[{"id":6236,"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/pages\/326\/revisions\/6236"}],"wp:attachment":[{"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/media?parent=326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}