{"id":454,"date":"2024-06-01T08:24:26","date_gmt":"2024-06-01T08:24:26","guid":{"rendered":"https:\/\/novaptech.com\/?page_id=454"},"modified":"2025-03-03T16:58:02","modified_gmt":"2025-03-03T16:58:02","slug":"custom-aptamer-selection-characterization","status":"publish","type":"page","link":"https:\/\/novaptech.com\/en\/custom-aptamer-selection-characterization\/","title":{"rendered":"Custom aptamers"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"454\" class=\"elementor elementor-454\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6732a555 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"6732a555\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-22a79c4 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"22a79c4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5c17683e elementor-widget elementor-widget-heading\" data-id=\"5c17683e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Custom aptamer selection &amp; characterization<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-59ef5e35 elementor-widget elementor-widget-heading\" data-id=\"59ef5e35\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Custom aptamer development<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f6141f9 elementor-widget elementor-widget-text-editor\" data-id=\"f6141f9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Novaptech selects aptamers against any kind of target : small natural or synthetic molecules, peptides, proteins, non pathogenic viruses and bacteria, eukaryotic cells.<br \/>We use proprietary libraries with random window of variable size according to the customer\u2019s need.<\/p><p>We select DNA, RNA or chemically-modified RNA aptamers.<br \/>We characterize the selected aptamers with respect to their binding properties and specificity of interaction with their target using Surface Plasmon Resonance, <span lang=\"EN-US\">BioLayer Interferometry or fluorescence emission<\/span><span style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var( --e-global-typography-text-font-size );\">.<\/span><\/p><p>We optimize the selected aptamer for easy and cost-effective synthesis and improved properties.<br \/>We provide samples of the selected and characterized aptamers through our partnership with\u00a0<span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/secure.eurogentec.com\/oligonucleotides.html\" target=\"_blank\" rel=\"noopener\">Eurogentec<\/a>.<\/span> Multiple kind of chemically-modified aptamers can be provided in small or large amounts, under GMP conditions if required.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6bd875e1 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"6bd875e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/novaptech.com\/en\/contact-us-aptamer-company-france-eu\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Tell us about your target<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2c3bb5e3 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"2c3bb5e3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1aca0f27 elementor-widget elementor-widget-image\" data-id=\"1aca0f27\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"369\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-2.jpg\" class=\"attachment-large size-large wp-image-457\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-2.jpg 600w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-2-300x185.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-155fcbc e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"155fcbc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-83568d4 elementor-widget elementor-widget-heading\" data-id=\"83568d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Eligible targets<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cfbb9e4 e-grid e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"cfbb9e4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7dce182 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"7dce182\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ec1518 elementor-widget elementor-widget-image\" data-id=\"9ec1518\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/small-molecule-aptamers.jpg\" class=\"attachment-large size-large wp-image-464\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/small-molecule-aptamers.jpg 1024w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/small-molecule-aptamers-300x300.jpg 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/small-molecule-aptamers-150x150.jpg 150w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/small-molecule-aptamers-768x768.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a405d2 elementor-widget elementor-widget-heading\" data-id=\"1a405d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Small natural or synthetic molecules<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-749a31c e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"749a31c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e68ad27 elementor-widget elementor-widget-image\" data-id=\"e68ad27\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/peptide.jpg\" class=\"attachment-large size-large wp-image-462\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/peptide.jpg 1024w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/peptide-300x300.jpg 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/peptide-150x150.jpg 150w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/peptide-768x768.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ac341e7 elementor-widget elementor-widget-heading\" data-id=\"ac341e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Peptides<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6946364 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"6946364\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-118881a elementor-widget elementor-widget-image\" data-id=\"118881a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/protein-targeting-aptamers.jpg\" class=\"attachment-large size-large wp-image-463\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/protein-targeting-aptamers.jpg 1024w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/protein-targeting-aptamers-300x300.jpg 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/protein-targeting-aptamers-150x150.jpg 150w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/protein-targeting-aptamers-768x768.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-06812cf elementor-widget elementor-widget-heading\" data-id=\"06812cf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Macromolecules\n\n<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9dd4611 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"9dd4611\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e076ed7 elementor-widget elementor-widget-image\" data-id=\"e076ed7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/virus-targeting-aptamers.jpg\" class=\"attachment-large size-large wp-image-465\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/virus-targeting-aptamers.jpg 1024w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/virus-targeting-aptamers-300x300.jpg 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/virus-targeting-aptamers-150x150.jpg 150w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/virus-targeting-aptamers-768x768.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b307eb4 elementor-widget elementor-widget-heading\" data-id=\"b307eb4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Virus &amp; bacteria<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fdf1721 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"fdf1721\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b62b7c5 elementor-widget elementor-widget-image\" data-id=\"b62b7c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/cell-targeting-aptamers.jpg\" class=\"attachment-large size-large wp-image-461\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/cell-targeting-aptamers.jpg 1024w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/cell-targeting-aptamers-300x300.jpg 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/cell-targeting-aptamers-150x150.jpg 150w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/cell-targeting-aptamers-768x768.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-433ee21 elementor-widget elementor-widget-heading\" data-id=\"433ee21\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Eukaryotic cells\n<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-90e3c60 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"90e3c60\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f4b10db elementor-widget elementor-widget-heading\" data-id=\"f4b10db\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Our process<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-21a2d55 elementor-widget elementor-widget-text-editor\" data-id=\"21a2d55\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Our selection process is divided into successive and independent phases.<br \/>A scientific report is provided after each phase that ends with a Go\/noGo.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-146d77f e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"146d77f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-a1253d8 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"a1253d8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-09692b5 elementor-widget elementor-widget-image\" data-id=\"09692b5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"412\" height=\"231\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto.jpg\" class=\"attachment-large size-large wp-image-473\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto.jpg 412w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-300x168.jpg 300w\" sizes=\"(max-width: 412px) 100vw, 412px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d84ba31 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"d84ba31\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9e8a1fa elementor-widget elementor-widget-heading\" data-id=\"9e8a1fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">0 - Feasibility study<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a6bcce elementor-widget elementor-widget-text-editor\" data-id=\"5a6bcce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Detailed discussion with a Novaptech senior scientist for defining the procedure and the conditions with respect to the customer\u2019s goal.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-14a3de3 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"14a3de3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-51b88a0 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"51b88a0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-245f80c elementor-widget elementor-widget-image\" data-id=\"245f80c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"412\" height=\"274\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-1.jpg\" class=\"attachment-large size-large wp-image-469\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-1.jpg 412w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-1-300x200.jpg 300w\" sizes=\"(max-width: 412px) 100vw, 412px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5462441 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"5462441\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-749952e elementor-widget elementor-widget-heading\" data-id=\"749952e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">1 - Initial screening<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7867a8b elementor-widget elementor-widget-text-editor\" data-id=\"7867a8b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Iterative steps of selection and amplification over a few rounds under increasing stringency. Selection may be run in parallel under different conditions. Counter (negative) selection can be introduced.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-db350d3 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"db350d3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-68f198e e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"68f198e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b7c3800 elementor-widget elementor-widget-image\" data-id=\"b7c3800\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"412\" height=\"274\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-2.jpg\" class=\"attachment-large size-large wp-image-470\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-2.jpg 412w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-2-300x200.jpg 300w\" sizes=\"(max-width: 412px) 100vw, 412px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-492ac12 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"492ac12\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bd508c8 elementor-widget elementor-widget-heading\" data-id=\"bd508c8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2 - Selection of polyclonal aptamers<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-99aa8cd elementor-widget elementor-widget-text-editor\" data-id=\"99aa8cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400;\">Additional rounds of selection are performed, from the last phase 1 pool. Pools are then submitted to Next Generation Sequencing. Candidates of interest are identified by bioinformatics (sequence homology, round to round evolution, secondary structure prediction) using proprietary algorithms.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d0bd3bd e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"d0bd3bd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-1bacbb7 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"1bacbb7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-160925b elementor-widget elementor-widget-image\" data-id=\"160925b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"412\" height=\"274\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-3.jpg\" class=\"attachment-large size-large wp-image-471\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-3.jpg 412w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-3-300x200.jpg 300w\" sizes=\"(max-width: 412px) 100vw, 412px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ebd929c e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"ebd929c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-11604fd elementor-widget elementor-widget-heading\" data-id=\"11604fd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">3 - Characterization of monoclonal aptamers<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5e430d4 elementor-widget elementor-widget-text-editor\" data-id=\"5e430d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A few representative candidates identified in phase 2 are synthesized and evaluated with respect to affinity and specificity of interaction with the target. The sequence of the best aptamer(s) is provided.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c3644b7 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"c3644b7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2db368d e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"2db368d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f87cd82 elementor-widget elementor-widget-image\" data-id=\"f87cd82\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"412\" height=\"274\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-4.jpg\" class=\"attachment-large size-large wp-image-472\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-4.jpg 412w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-4-300x200.jpg 300w\" sizes=\"(max-width: 412px) 100vw, 412px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-11a3498 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"11a3498\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b5a040b elementor-widget elementor-widget-heading\" data-id=\"b5a040b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">4 - Optimization of the selected aptamer<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-941ea26 elementor-widget elementor-widget-text-editor\" data-id=\"941ea26\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The selected aptamers can be further optimized depending on the type of assay they will be used in. The crude selected aptamer can be trimmed for eliminating portions not necessary for binding. The resulting truncated aptamer can then be chemically modified or conjugated to various pending groups for making it resistant to nucleases or for detection by fluorescence, for instance. Other modifications can be introduced and tested.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-813f64d e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"813f64d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0c2950c e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"0c2950c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-576201b elementor-widget elementor-widget-image\" data-id=\"576201b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.eurogentec.com\/en\/oligos-aptamers\" target=\"_blank\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"412\" height=\"231\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-6.jpg\" class=\"attachment-large size-large wp-image-474\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-6.jpg 412w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_412_0_0_0_auto-6-300x168.jpg 300w\" sizes=\"(max-width: 412px) 100vw, 412px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fe097d4 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"fe097d4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ef0e86 elementor-widget elementor-widget-heading\" data-id=\"9ef0e86\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">5 - Aptamer synthesis<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c32e65 elementor-widget elementor-widget-text-editor\" data-id=\"4c32e65\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Novaptech provides a tiny amount of the selected aptamer to the customer for the first trials. Larger amounts of aptamer with numerous chemical modification can be obtained from our partner, <span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/www.eurogentec.com\/en\/oligos-aptamers\" target=\"_blank\" rel=\"noopener\">Eurogentec.<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-08caa5b elementor-align-center elementor-widget elementor-widget-button\" data-id=\"08caa5b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/novaptech.com\/en\/aptamer-based-assay-development-services\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Aptamer-based assays development<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-08a5047 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"08a5047\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-06ee3ff elementor-widget elementor-widget-heading\" data-id=\"06ee3ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Novaptech added-value<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-10f1d15 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"10f1d15\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-44a8971 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"44a8971\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6718146 elementor-widget elementor-widget-image\" data-id=\"6718146\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/novaptech.com\/aptamer-company\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"348\" height=\"196\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-7.jpg\" class=\"attachment-large size-large wp-image-986\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-7.jpg 348w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-7-300x169.jpg 300w\" sizes=\"(max-width: 348px) 100vw, 348px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56d3fce elementor-widget elementor-widget-heading\" data-id=\"56d3fce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Scientist-to-scientist interactions<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65edc6a elementor-widget elementor-widget-heading\" data-id=\"65edc6a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">With Novaptech you benefit from nearly 30 years experience on aptamers. From the very early stage of your project you have a personal contact with one of our senior scientists for evaluating the feasibility, designing the library and the selection procedure, defining the chemical modifications and the assay. Feedback is provided at every step of your project.<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-63ddb2a elementor-align-center elementor-widget elementor-widget-button\" data-id=\"63ddb2a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/novaptech.com\/aptamer-company\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">More about Novaptech<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-58cae4b e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"58cae4b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7a2caa1 elementor-widget elementor-widget-video\" data-id=\"7a2caa1\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;vimeo&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/novaptech-com.preview-domain.com\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/thumb_348_196_0_0_crop.png&quot;,&quot;id&quot;:294,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;&quot;,&quot;source&quot;:&quot;library&quot;}}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<iframe class=\"elementor-video-iframe\" allowfullscreen allow=\"clipboard-write\" title=\"vimeo Video Player\" src=\"https:\/\/player.vimeo.com\/video\/267761524?color&amp;autopause=0&amp;loop=0&amp;muted=0&amp;title=1&amp;portrait=1&amp;byline=1#t=\"><\/iframe>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop.png);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Play Video\" tabindex=\"0\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-eicon-play\" viewBox=\"0 0 1000 1000\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M838 162C746 71 633 25 500 25 371 25 258 71 163 162 71 254 25 367 25 500 25 633 71 746 163 837 254 929 367 979 500 979 633 979 746 933 838 837 929 746 975 633 975 500 975 367 929 254 838 162M808 192C892 279 933 379 933 500 933 621 892 725 808 808 725 892 621 938 500 938 379 938 279 896 196 808 113 725 67 621 67 500 67 379 108 279 196 192 279 108 383 62 500 62 621 62 721 108 808 192M438 392V642L642 517 438 392Z\"><\/path><\/svg>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c937c4f elementor-widget elementor-widget-heading\" data-id=\"c937c4f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Cutting-edge aptamer technologies<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-29459a1 elementor-widget elementor-widget-heading\" data-id=\"29459a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Our R&amp;D researchers develop innovative processes for aptamer selection and assay design, which are immediately offered to our clients. At Novaptech, our activities focus on a particular class of aptamers, \u00ab aptaswitches \u00bb leveraging the unique NOVAswitch technology.<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0bd7dfd elementor-align-center elementor-widget elementor-widget-button\" data-id=\"0bd7dfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/novaptech.com\/second-generation-aptamers-selkiss-aptaswitch\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Learn about our technology<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6205868 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"6205868\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a90e578 elementor-widget elementor-widget-image\" data-id=\"a90e578\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/entreprendre.service-public.fr\/vosdroits\/F23533\" target=\"_blank\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"348\" height=\"196\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-4.jpg\" class=\"attachment-large size-large wp-image-292\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-4.jpg 348w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-4-300x169.jpg 300w\" sizes=\"(max-width: 348px) 100vw, 348px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-14b0fdb elementor-widget elementor-widget-heading\" data-id=\"14b0fdb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">French Research Tax Credit certified<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b72c8b0 elementor-widget elementor-widget-text-editor\" data-id=\"b72c8b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Novaptech has been approved for the Research Tax Credit from 2020 to 2027. Novaptech customers can benefit from a refundable tax credit for R&amp;D services entrusted to Novaptech.<br \/>You can view the certification <span style=\"text-decoration: underline; color: #808080;\"><a style=\"color: #808080; text-decoration: underline;\" href=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/02\/NOVAPTECH-Certificat-agrement-CIR-2025-1.pdf\">here<\/a><\/span>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eac78bc elementor-align-center elementor-widget elementor-widget-button\" data-id=\"eac78bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/entreprendre.service-public.fr\/vosdroits\/F23533\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">See conditions here<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8c9a92f e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"8c9a92f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cdf3a75 elementor-widget elementor-widget-image\" data-id=\"cdf3a75\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.eurogentec.com\/en\/oligos-aptamers\" target=\"_blank\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"348\" height=\"196\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-3.jpg\" class=\"attachment-large size-large wp-image-291\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-3.jpg 348w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_348_196_0_0_crop-3-300x169.jpg 300w\" sizes=\"(max-width: 348px) 100vw, 348px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-044de68 elementor-widget elementor-widget-heading\" data-id=\"044de68\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Industrial capacities through Eurogentec<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2058e7d elementor-widget elementor-widget-heading\" data-id=\"2058e7d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Eurogentec provides products and services to scientists involved in life science research, molecular diagnostics and therapeutic developments. Expert in small and large-scale synthesis, Eurogentec produces a wide range of custom oligonucleotides from classical primers up to highly complex sequences. Novaptech and Eurogentec signed a partnership for the production of aptamers selected by Novaptech.<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2883a81 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"2883a81\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.eurogentec.com\/en\/oligos-aptamers\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Visit Eurogentec website<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4f5c4e14 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"4f5c4e14\" data-element_type=\"container\" data-e-type=\"container\" id=\"contact\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-71a302eb e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"71a302eb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6506ab2f elementor-widget elementor-widget-heading\" data-id=\"6506ab2f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Tell us about your target<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a400f95 elementor-widget elementor-widget-heading\" data-id=\"1a400f95\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Any question about selection service or assay development ? Please fill in the form below with relevant details for helping us providing an informative answer. Telephone or video call can be arranged. NDA can be signed, would you wish so. We will answer you as quickly as possible (generally less than 2 working days).<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d5d3f0e e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"d5d3f0e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2c0bcdf elementor-align-center elementor-widget elementor-widget-button\" data-id=\"2c0bcdf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/novaptech.com\/contact-us-aptamer-company-france-eu\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contact us<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4dff42b5 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"4dff42b5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2dcde119 elementor-widget elementor-widget-image\" data-id=\"2dcde119\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"337\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/thumb_600_0_0_0_auto-2.jpg\" class=\"attachment-full size-full wp-image-183\" alt=\"Biomarker analysis\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/thumb_600_0_0_0_auto-2.jpg 600w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/05\/thumb_600_0_0_0_auto-2-300x169.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-646d3b82 elementor-widget elementor-widget-heading\" data-id=\"646d3b82\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Your scientific contact :<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-223ec1ab elementor-widget elementor-widget-heading\" data-id=\"223ec1ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Jean-Jacques Toulm\u00e9, PhD, CSO<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Custom aptamer selection &amp; characterization Custom aptamer development Novaptech selects aptamers against any kind of target : small natural or synthetic molecules, peptides, proteins, non pathogenic viruses and bacteria, eukaryotic cells.We use proprietary libraries with random window of variable size according to the customer\u2019s need. We select DNA, RNA or chemically-modified RNA aptamers.We characterize the selected aptamers with respect to their binding properties and specificity of interaction with their target using Surface Plasmon Resonance, BioLayer Interferometry or fluorescence emission. We optimize the selected aptamer for easy and cost-effective synthesis and improved properties.We provide samples of the selected and characterized aptamers through our partnership with\u00a0Eurogentec. Multiple kind of chemically-modified aptamers can be provided in small or large amounts, under GMP conditions if required. Tell us about your target Eligible targets Small natural or synthetic molecules Peptides Macromolecules Virus &amp; bacteria Eukaryotic cells Our process Our selection process is divided into successive and independent phases.A scientific report is provided after each phase that ends with a Go\/noGo. 0 &#8211; Feasibility study Detailed discussion with a Novaptech senior scientist for defining the procedure and the conditions with respect to the customer\u2019s goal. 1 &#8211; Initial screening Iterative steps of selection and amplification over a few rounds under increasing stringency. Selection may be run in parallel under different conditions. Counter (negative) selection can be introduced. 2 &#8211; Selection of polyclonal aptamers Additional rounds of selection are performed, from the last phase 1 pool. Pools are then submitted to Next Generation Sequencing. Candidates of interest are identified by bioinformatics (sequence homology, round to round evolution, secondary structure prediction) using proprietary algorithms. 3 &#8211; Characterization of monoclonal aptamers A few representative candidates identified in phase 2 are synthesized and evaluated with respect to affinity and specificity of interaction with the target. The sequence of the best aptamer(s) is provided. 4 &#8211; Optimization of the selected aptamer The selected aptamers can be further optimized depending on the type of assay they will be used in. The crude selected aptamer can be trimmed for eliminating portions not necessary for binding. The resulting truncated aptamer can then be chemically modified or conjugated to various pending groups for making it resistant to nucleases or for detection by fluorescence, for instance. Other modifications can be introduced and tested. 5 &#8211; Aptamer synthesis Novaptech provides a tiny amount of the selected aptamer to the customer for the first trials. Larger amounts of aptamer with numerous chemical modification can be obtained from our partner, Eurogentec. Aptamer-based assays development Novaptech added-value Scientist-to-scientist interactions With Novaptech you benefit from nearly 30 years experience on aptamers. From the very early stage of your project you have a personal contact with one of our senior scientists for evaluating the feasibility, designing the library and the selection procedure, defining the chemical modifications and the assay. Feedback is provided at every step of your project. More about Novaptech Cutting-edge aptamer technologies Our R&amp;D researchers develop innovative processes for aptamer selection and assay design, which are immediately offered to our clients. At Novaptech, our activities focus on a particular class of aptamers, \u00ab aptaswitches \u00bb leveraging the unique NOVAswitch technology. Learn about our technology French Research Tax Credit certified Novaptech has been approved for the Research Tax Credit from 2020 to 2027. Novaptech customers can benefit from a refundable tax credit for R&amp;D services entrusted to Novaptech.You can view the certification here. See conditions here Industrial capacities through Eurogentec Eurogentec provides products and services to scientists involved in life science research, molecular diagnostics and therapeutic developments. Expert in small and large-scale synthesis, Eurogentec produces a wide range of custom oligonucleotides from classical primers up to highly complex sequences. Novaptech and Eurogentec signed a partnership for the production of aptamers selected by Novaptech. Visit Eurogentec website Tell us about your target Any question about selection service or assay development ? Please fill in the form below with relevant details for helping us providing an informative answer. Telephone or video call can be arranged. NDA can be signed, would you wish so. We will answer you as quickly as possible (generally less than 2 working days). Contact us Your scientific contact : Jean-Jacques Toulm\u00e9, PhD, CSO<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-454","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Custom aptamers - Novaptech<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/novaptech.com\/en\/custom-aptamer-selection-characterization\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Custom aptamers - Novaptech\" \/>\n<meta property=\"og:description\" content=\"Custom aptamer selection &amp; characterization Custom aptamer development Novaptech selects aptamers against any kind of target : small natural or synthetic molecules, peptides, proteins, non pathogenic viruses and bacteria, eukaryotic cells.We use proprietary libraries with random window of variable size according to the customer\u2019s need. We select DNA, RNA or chemically-modified RNA aptamers.We characterize the selected aptamers with respect to their binding properties and specificity of interaction with their target using Surface Plasmon Resonance, BioLayer Interferometry or fluorescence emission. We optimize the selected aptamer for easy and cost-effective synthesis and improved properties.We provide samples of the selected and characterized aptamers through our partnership with\u00a0Eurogentec. Multiple kind of chemically-modified aptamers can be provided in small or large amounts, under GMP conditions if required. Tell us about your target Eligible targets Small natural or synthetic molecules Peptides Macromolecules Virus &amp; bacteria Eukaryotic cells Our process Our selection process is divided into successive and independent phases.A scientific report is provided after each phase that ends with a Go\/noGo. 0 &#8211; Feasibility study Detailed discussion with a Novaptech senior scientist for defining the procedure and the conditions with respect to the customer\u2019s goal. 1 &#8211; Initial screening Iterative steps of selection and amplification over a few rounds under increasing stringency. Selection may be run in parallel under different conditions. Counter (negative) selection can be introduced. 2 &#8211; Selection of polyclonal aptamers Additional rounds of selection are performed, from the last phase 1 pool. Pools are then submitted to Next Generation Sequencing. Candidates of interest are identified by bioinformatics (sequence homology, round to round evolution, secondary structure prediction) using proprietary algorithms. 3 &#8211; Characterization of monoclonal aptamers A few representative candidates identified in phase 2 are synthesized and evaluated with respect to affinity and specificity of interaction with the target. The sequence of the best aptamer(s) is provided. 4 &#8211; Optimization of the selected aptamer The selected aptamers can be further optimized depending on the type of assay they will be used in. The crude selected aptamer can be trimmed for eliminating portions not necessary for binding. The resulting truncated aptamer can then be chemically modified or conjugated to various pending groups for making it resistant to nucleases or for detection by fluorescence, for instance. Other modifications can be introduced and tested. 5 &#8211; Aptamer synthesis Novaptech provides a tiny amount of the selected aptamer to the customer for the first trials. Larger amounts of aptamer with numerous chemical modification can be obtained from our partner, Eurogentec. Aptamer-based assays development Novaptech added-value Scientist-to-scientist interactions With Novaptech you benefit from nearly 30 years experience on aptamers. From the very early stage of your project you have a personal contact with one of our senior scientists for evaluating the feasibility, designing the library and the selection procedure, defining the chemical modifications and the assay. Feedback is provided at every step of your project. More about Novaptech Cutting-edge aptamer technologies Our R&amp;D researchers develop innovative processes for aptamer selection and assay design, which are immediately offered to our clients. At Novaptech, our activities focus on a particular class of aptamers, \u00ab aptaswitches \u00bb leveraging the unique NOVAswitch technology. Learn about our technology French Research Tax Credit certified Novaptech has been approved for the Research Tax Credit from 2020 to 2027. Novaptech customers can benefit from a refundable tax credit for R&amp;D services entrusted to Novaptech.You can view the certification here. See conditions here Industrial capacities through Eurogentec Eurogentec provides products and services to scientists involved in life science research, molecular diagnostics and therapeutic developments. Expert in small and large-scale synthesis, Eurogentec produces a wide range of custom oligonucleotides from classical primers up to highly complex sequences. Novaptech and Eurogentec signed a partnership for the production of aptamers selected by Novaptech. Visit Eurogentec website Tell us about your target Any question about selection service or assay development ? Please fill in the form below with relevant details for helping us providing an informative answer. Telephone or video call can be arranged. NDA can be signed, would you wish so. We will answer you as quickly as possible (generally less than 2 working days). Contact us Your scientific contact : Jean-Jacques Toulm\u00e9, PhD, CSO\" \/>\n<meta property=\"og:url\" content=\"https:\/\/novaptech.com\/en\/custom-aptamer-selection-characterization\/\" \/>\n<meta property=\"og:site_name\" content=\"Novaptech\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-03T16:58:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-2.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/\",\"url\":\"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/\",\"name\":\"Custom aptamers - Novaptech\",\"isPartOf\":{\"@id\":\"https:\/\/novaptech.com\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-2.jpg\",\"datePublished\":\"2024-06-01T08:24:26+00:00\",\"dateModified\":\"2025-03-03T16:58:02+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/#primaryimage\",\"url\":\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-2.jpg\",\"contentUrl\":\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-2.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/novaptech.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Custom aptamers\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/novaptech.com\/en\/#website\",\"url\":\"https:\/\/novaptech.com\/en\/\",\"name\":\"Novaptech\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/novaptech.com\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/novaptech.com\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/novaptech.com\/en\/#organization\",\"name\":\"Novaptech\",\"url\":\"https:\/\/novaptech.com\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/novaptech.com\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/cropped-LOGO.png\",\"contentUrl\":\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/cropped-LOGO.png\",\"width\":335,\"height\":140,\"caption\":\"Novaptech\"},\"image\":{\"@id\":\"https:\/\/novaptech.com\/en\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Custom aptamers - Novaptech","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/novaptech.com\/en\/custom-aptamer-selection-characterization\/","og_locale":"en_US","og_type":"article","og_title":"Custom aptamers - Novaptech","og_description":"Custom aptamer selection &amp; characterization Custom aptamer development Novaptech selects aptamers against any kind of target : small natural or synthetic molecules, peptides, proteins, non pathogenic viruses and bacteria, eukaryotic cells.We use proprietary libraries with random window of variable size according to the customer\u2019s need. We select DNA, RNA or chemically-modified RNA aptamers.We characterize the selected aptamers with respect to their binding properties and specificity of interaction with their target using Surface Plasmon Resonance, BioLayer Interferometry or fluorescence emission. We optimize the selected aptamer for easy and cost-effective synthesis and improved properties.We provide samples of the selected and characterized aptamers through our partnership with\u00a0Eurogentec. Multiple kind of chemically-modified aptamers can be provided in small or large amounts, under GMP conditions if required. Tell us about your target Eligible targets Small natural or synthetic molecules Peptides Macromolecules Virus &amp; bacteria Eukaryotic cells Our process Our selection process is divided into successive and independent phases.A scientific report is provided after each phase that ends with a Go\/noGo. 0 &#8211; Feasibility study Detailed discussion with a Novaptech senior scientist for defining the procedure and the conditions with respect to the customer\u2019s goal. 1 &#8211; Initial screening Iterative steps of selection and amplification over a few rounds under increasing stringency. Selection may be run in parallel under different conditions. Counter (negative) selection can be introduced. 2 &#8211; Selection of polyclonal aptamers Additional rounds of selection are performed, from the last phase 1 pool. Pools are then submitted to Next Generation Sequencing. Candidates of interest are identified by bioinformatics (sequence homology, round to round evolution, secondary structure prediction) using proprietary algorithms. 3 &#8211; Characterization of monoclonal aptamers A few representative candidates identified in phase 2 are synthesized and evaluated with respect to affinity and specificity of interaction with the target. The sequence of the best aptamer(s) is provided. 4 &#8211; Optimization of the selected aptamer The selected aptamers can be further optimized depending on the type of assay they will be used in. The crude selected aptamer can be trimmed for eliminating portions not necessary for binding. The resulting truncated aptamer can then be chemically modified or conjugated to various pending groups for making it resistant to nucleases or for detection by fluorescence, for instance. Other modifications can be introduced and tested. 5 &#8211; Aptamer synthesis Novaptech provides a tiny amount of the selected aptamer to the customer for the first trials. Larger amounts of aptamer with numerous chemical modification can be obtained from our partner, Eurogentec. Aptamer-based assays development Novaptech added-value Scientist-to-scientist interactions With Novaptech you benefit from nearly 30 years experience on aptamers. From the very early stage of your project you have a personal contact with one of our senior scientists for evaluating the feasibility, designing the library and the selection procedure, defining the chemical modifications and the assay. Feedback is provided at every step of your project. More about Novaptech Cutting-edge aptamer technologies Our R&amp;D researchers develop innovative processes for aptamer selection and assay design, which are immediately offered to our clients. At Novaptech, our activities focus on a particular class of aptamers, \u00ab aptaswitches \u00bb leveraging the unique NOVAswitch technology. Learn about our technology French Research Tax Credit certified Novaptech has been approved for the Research Tax Credit from 2020 to 2027. Novaptech customers can benefit from a refundable tax credit for R&amp;D services entrusted to Novaptech.You can view the certification here. See conditions here Industrial capacities through Eurogentec Eurogentec provides products and services to scientists involved in life science research, molecular diagnostics and therapeutic developments. Expert in small and large-scale synthesis, Eurogentec produces a wide range of custom oligonucleotides from classical primers up to highly complex sequences. Novaptech and Eurogentec signed a partnership for the production of aptamers selected by Novaptech. Visit Eurogentec website Tell us about your target Any question about selection service or assay development ? Please fill in the form below with relevant details for helping us providing an informative answer. Telephone or video call can be arranged. NDA can be signed, would you wish so. We will answer you as quickly as possible (generally less than 2 working days). Contact us Your scientific contact : Jean-Jacques Toulm\u00e9, PhD, CSO","og_url":"https:\/\/novaptech.com\/en\/custom-aptamer-selection-characterization\/","og_site_name":"Novaptech","article_modified_time":"2025-03-03T16:58:02+00:00","og_image":[{"url":"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-2.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/","url":"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/","name":"Custom aptamers - Novaptech","isPartOf":{"@id":"https:\/\/novaptech.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/#primaryimage"},"image":{"@id":"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/#primaryimage"},"thumbnailUrl":"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-2.jpg","datePublished":"2024-06-01T08:24:26+00:00","dateModified":"2025-03-03T16:58:02+00:00","breadcrumb":{"@id":"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/#primaryimage","url":"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-2.jpg","contentUrl":"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-2.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/novaptech.com\/en\/"},{"@type":"ListItem","position":2,"name":"Custom aptamers"}]},{"@type":"WebSite","@id":"https:\/\/novaptech.com\/en\/#website","url":"https:\/\/novaptech.com\/en\/","name":"Novaptech","description":"","publisher":{"@id":"https:\/\/novaptech.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/novaptech.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/novaptech.com\/en\/#organization","name":"Novaptech","url":"https:\/\/novaptech.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/novaptech.com\/en\/#\/schema\/logo\/image\/","url":"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/cropped-LOGO.png","contentUrl":"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/cropped-LOGO.png","width":335,"height":140,"caption":"Novaptech"},"image":{"@id":"https:\/\/novaptech.com\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/pages\/454","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/comments?post=454"}],"version-history":[{"count":74,"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/pages\/454\/revisions"}],"predecessor-version":[{"id":4617,"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/pages\/454\/revisions\/4617"}],"wp:attachment":[{"href":"https:\/\/novaptech.com\/en\/wp-json\/wp\/v2\/media?parent=454"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}