{"id":4864,"date":"2025-06-16T13:06:45","date_gmt":"2025-06-16T13:06:45","guid":{"rendered":"https:\/\/novaptech.com\/?page_id=4864"},"modified":"2025-06-16T13:32:04","modified_gmt":"2025-06-16T13:32:04","slug":"biosensors","status":"publish","type":"page","link":"https:\/\/novaptech.com\/en\/biosensors\/","title":{"rendered":"Biosensors"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4864\" class=\"elementor elementor-4864\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8de3f03 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"8de3f03\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1c21df4 elementor-widget elementor-widget-spacer\" data-id=\"1c21df4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3b72ad9 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"3b72ad9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4261003 elementor-widget elementor-widget-heading\" data-id=\"4261003\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Sensitive detection of analytes with NOVAswitch aptasensors (aptamer-based biosensors).<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-acc92b1 elementor-widget elementor-widget-text-editor\" data-id=\"acc92b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400;\">Aptamers are chemically synthesized oligonucleotides. They can be easily conjugated to various functional groups for grafting, immobilization or signaling. This includes (but is not restricted to) amino -NH2, carboxyl -COOH or thiol -SH functions, fluorescent (FAM, Alexa, Cyanine) or redox (methylene blue) reporters. A spacer can be introduced between these groups and either the 5\u2019 or 3\u2019 end of the aptamer. Through our privileged partner, <a href=\"https:\/\/www.eurogentec.com\/en\/oligos-aptamers\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #923393;\">Eurogentec<\/span><\/a> , our customers have full access to such functionally modified aptamers.<\/p><p>Aptamers are easily integrated into biosensors, utilizing different signal transduction modalities. At Novaptech, we routinely use Surface Plasmon Resonance (SPR) and Bio-Layer Interferometry (BLI) to characterize aptamer binding (<span style=\"color: #923393;\"><a style=\"color: #923393;\" href=\"https:\/\/novaptech.com\/custom-aptamer-selection-characterization\/\" target=\"_blank\" rel=\"noopener\">see Novaptech Custom aptamer selection &amp; characterization process<\/a><\/span>).<\/p><p style=\"font-weight: 400;\"><span style=\"color: #923393;\"><strong>Additionally, Novaptech engineers aptamer-based fluorescent and colorimetric aptasensors for the detection of small molecules and proteins.<\/strong><\/span><\/p><p style=\"font-weight: 400;\">Our NOVAswitches simplify the design of aptasensors. The structural change induced by the binding of the target to its cognate aptamer is exploited for the emission of a signal. Therefore, our NOVAswitch aptasensors ensure the specific and quantitative detection of the molecule of interest.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4b58252 e-grid e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"4b58252\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-86a3e05 elementor-widget elementor-widget-image\" data-id=\"86a3e05\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto.jpg\" class=\"attachment-large size-large wp-image-331\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto.jpg 600w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-300x200.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-376d3a7 elementor-widget elementor-widget-image\" data-id=\"376d3a7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-1.jpg\" class=\"attachment-large size-large wp-image-341\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-1.jpg 600w, https:\/\/novaptech.com\/wp-content\/uploads\/2024\/06\/thumb_600_0_0_0_auto-1-300x200.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7c38193 elementor-widget elementor-widget-text-editor\" data-id=\"7c38193\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400; text-align: center;\"><em>NOVAswitch in its free form (left) and bound to its target (right).<\/em><\/p><p>\u00a0<\/p><h3 style=\"font-weight: 400; text-align: center;\"><strong><span style=\"color: #923393;\">Novaptech can engineer an aptasensor from your own aptamer. Please,<span style=\"color: #923393;\"> <a style=\"color: #923393;\" href=\"https:\/\/novaptech.com\/contact-us-aptamer-company-france-eu\/\" target=\"_blank\" rel=\"noopener\">contact<\/a> <\/span>us!<\/span><\/strong><\/h3><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-00ca5a0 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"00ca5a0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-881b722 elementor-widget elementor-widget-heading\" data-id=\"881b722\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Fluorescent NOVAswitch Aptasensors <\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cef9551 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"cef9551\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-51482ff elementor-widget elementor-widget-text-editor\" data-id=\"51482ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400;\">Fluorescence can be used in several ways in NOVAswitch aptasensors:<\/p><ul><li>Molecular beacons<\/li><li>Energy transfer<\/li><li>Fluorescence anisotropy<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1305f0d e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"1305f0d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0aeb297 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"0aeb297\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-340425b elementor-widget elementor-widget-heading\" data-id=\"340425b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Molecular beacon \u2013 Structure switching aptamers NOVAswitch<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c863d5a elementor-widget elementor-widget-text-editor\" data-id=\"c863d5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400;\">A bi-molecular beacon is a combination of a fluorescently labeled aptamer and a short complementary oligonucleotide conjugated to a quencher. The close proximity between the fluorophore and the quencher inhibits the emission of light. When the target molecule binds to the aptamer, it induces a structural change of the NOVAswitch and releases the quenching oligonucleotide, resulting in fluorescence emission that correlates with the target molecule concentration.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-feb5f9b elementor-widget__width-initial elementor-widget elementor-widget-image-gallery\" data-id=\"feb5f9b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-1' class='gallery galleryid-4864 gallery-columns-1 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img decoding=\"async\" width=\"531\" height=\"170\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/MB.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/MB.png 531w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/MB-300x96.png 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/MB-18x6.png 18w\" sizes=\"(max-width: 531px) 100vw, 531px\" \/>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8ec92e5 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"8ec92e5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4afdde1 elementor-widget elementor-widget-text-editor\" data-id=\"4afdde1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400; text-align: center;\"><em>Scheme of a molecular beacon assay<\/em><\/p><p style=\"font-weight: 400;\">Novaptech has designed molecular beacon-based aptasensors for the detection of various antibiotics .The example below shows a typical assay for the specific detection of streptomycine by a beacon made of a FAM-conjugated NOVAswitch combined with a BHQ1-conjugated complementary oligonucleotide.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c9db655 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"c9db655\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-80c18d0 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"80c18d0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4661c52 elementor-widget__width-initial elementor-widget elementor-widget-image-gallery\" data-id=\"4661c52\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-2' class='gallery galleryid-4864 gallery-columns-1 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"432\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/Streptomyci-kana-graph-3-1024x553.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/Streptomyci-kana-graph-3-1024x553.png 1024w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/Streptomyci-kana-graph-3-300x162.png 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/Streptomyci-kana-graph-3-768x415.png 768w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/Streptomyci-kana-graph-3-1536x830.png 1536w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/Streptomyci-kana-graph-3-18x10.png 18w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/Streptomyci-kana-graph-3.png 1897w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4852a22 elementor-widget elementor-widget-text-editor\" data-id=\"4852a22\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400; text-align: center;\"><em>Fluorescence intensity as a function of antibiotic concentration, demonstrating the specific detection of streptomycin using a molecular beacon-based NOVAswitch aptasensor.\u00a0<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8d05610 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"8d05610\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-08f396f e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"08f396f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-956d709 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"956d709\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-16b19a8 elementor-widget elementor-widget-heading\" data-id=\"16b19a8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Energy transfer with Lanthanide nanoparticles - Structure switching aptamers NOVAswitch<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-25a4bfe elementor-widget elementor-widget-text-editor\" data-id=\"25a4bfe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400;\">Lanthanide (La) nanoparticles (NPs) are characterized by bright, long-lived fluorescence emission. This fluorescence is quenched when energy is transferred to a dye. In collaboration with <a href=\"https:\/\/poly-dtech.com\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #923393;\">Poly-DTech<\/span><\/a> , we designed a NOVAswitch-based aptasensor that combines La particles grafted with a short oligonucleotide complementary to part of an aptamer, which is conjugated to a dye. <a href=\"https:\/\/poly-dtech.com\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-4913\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/cropped-logo-poly-dtech-e1654557708393-300x138.png\" alt=\"\" width=\"109\" height=\"50\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/cropped-logo-poly-dtech-e1654557708393-300x138.png 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/cropped-logo-poly-dtech-e1654557708393-1024x473.png 1024w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/cropped-logo-poly-dtech-e1654557708393-768x354.png 768w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/cropped-logo-poly-dtech-e1654557708393-1536x709.png 1536w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/cropped-logo-poly-dtech-e1654557708393-2048x945.png 2048w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/cropped-logo-poly-dtech-e1654557708393-18x8.png 18w\" sizes=\"(max-width: 109px) 100vw, 109px\" \/><\/a><\/p><p style=\"font-weight: 400;\">The binding of the target molecule to the aptamer induces a structural change of the NOVAswitch and dissociates the oligonucleotide hybrid, thereby preventing energy transfer from the nanoparticle to the acceptor, hence allowing the fluorescence emission of the La particle.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7de4003 elementor-widget__width-initial elementor-widget elementor-widget-image-gallery\" data-id=\"7de4003\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-3' class='gallery galleryid-4864 gallery-columns-1 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"275\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/Lanthanide-1-1024x352.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/Lanthanide-1-1024x352.png 1024w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/Lanthanide-1-300x103.png 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/Lanthanide-1-768x264.png 768w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/Lanthanide-1-1536x528.png 1536w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/Lanthanide-1-18x6.png 18w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/Lanthanide-1.png 2004w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c39810d e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"c39810d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fba022a elementor-widget elementor-widget-text-editor\" data-id=\"fba022a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400; text-align: center;\"><em>Scheme of La-NP-based NOVAswitch aptasensor<\/em><\/p><div><p><span lang=\"EN-US\">Novaptech has developed La-nanoparticle-based aptasensors for the detection of various fungicides<\/span>.<\/p><p style=\"font-weight: 400;\">The example below shows a typical assay for the specific and quantitative detection of thiabendazole (TBZ) using a sensor that includes a dye-conjugated NOVAswitch. La NP-NOVAswitch aptasensors, which enable the measurement of delayed fluorescence, are particularly useful for the quantitative detection of analytes in complex matrices with high fluorescence backgrounds.<\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e383201 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"e383201\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-9206a61 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"9206a61\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-40df939 elementor-widget__width-initial elementor-widget elementor-widget-image-gallery\" data-id=\"40df939\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-4' class='gallery galleryid-4864 gallery-columns-1 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"466\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/TBZ-1024x596.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/TBZ-1024x596.png 1024w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/TBZ-300x174.png 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/TBZ-768x447.png 768w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/TBZ-1536x893.png 1536w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/TBZ-18x10.png 18w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/TBZ.png 1747w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a09bf95 elementor-widget elementor-widget-text-editor\" data-id=\"a09bf95\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div style=\"text-align: center;\"><i><span lang=\"EN-US\">FRET response as a function of thiabendazole (TBZ) concentration, using La NP-based NOVAswitch aptasensors<\/span><\/i><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6aa2c07 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"6aa2c07\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-9ee3583 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"9ee3583\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-0b10a70 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"0b10a70\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-7dfdcfe e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"7dfdcfe\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4fc4740 elementor-widget elementor-widget-heading\" data-id=\"4fc4740\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Fluorescence anisotropy-based aptasensor - Structure switching aptamers NOVAswitch<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8251099 elementor-widget elementor-widget-text-editor\" data-id=\"8251099\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400;\">In this particular format we take advantage of the change in the molecular weight, i.e. the mobility that accompanies the conformational modification of the NOVAswitch in response to the binding to its target.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b113997 elementor-widget elementor-widget-text-editor\" data-id=\"b113997\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 class=\"c-article-title\" data-test=\"article-title\"><strong><span style=\"color: #923393;\"><a href=\"https:\/\/doi.org\/10.1007\/s00216-015-8818-8\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4899 size-medium alignleft\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/publi-1-aptasensor-300x111.png\" alt=\"\" width=\"300\" height=\"111\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/publi-1-aptasensor-300x111.png 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/publi-1-aptasensor-1024x380.png 1024w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/publi-1-aptasensor-768x285.png 768w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/publi-1-aptasensor-18x7.png 18w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/publi-1-aptasensor.png 1302w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/span><\/strong><\/h4><h4 data-test=\"article-title\"><a style=\"font-family: inherit; font-size: 1.5rem;\" href=\"https:\/\/doi.org\/10.1007\/s00216-015-8818-8\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #923393;\"><strong>An improved design of the kissing complex-based aptasensor for the detection of adenosine<\/strong><\/span><\/a><\/h4><h6>\u00a0<\/h6><p style=\"font-weight: 400;\"><span style=\"color: #333333;\">\u00a0<\/span><\/p><div><span lang=\"EN-US\">Goux, E., Lisi, S., Ravelet, C., Durand, G., Fiore, E., Dausse, E., Toulm\u00e9, J. J., &amp; Peyrin, E.<\/span><\/div><div>\u00a0<\/div><p style=\"font-weight: 400;\"><span style=\"color: #333333;\"><em>Keywords: aptamer biosensing, dual recognition, nucleic acid assembly, aptaswitch, loop-loop interactions, kissing complex, fluorescence anisotropy, adenosine-adenoswitch, fluorophore-labeled aptakiss, blocking DNA, detection limit, human serum, biosensor optimization.<\/em><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e9b1ed5 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"e9b1ed5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-6dbd717 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"6dbd717\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5b3cd90 elementor-widget elementor-widget-heading\" data-id=\"5b3cd90\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Electronic conduction (BIOFET) NOVAswitch aptasensors<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17f86c9 elementor-widget elementor-widget-text-editor\" data-id=\"17f86c9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400;\">Novaptech, in collaboration with <a href=\"https:\/\/grapheal.com\/#section-industry\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #923393;\">Grapheal<\/span> <\/a>is developing a BIOFET-based NOVAswitch sensor for the detection of biomolecules of interest in health sciences. Grapheal is a French spin-off from CNRS-Grenoble which markets a new sensitive material, graphene on polymer, capable of measuring variations in electronic conduction (BIOFET principle). It has developed \u201cGraphLAB\u201d a chemical and biological field analytical sensor capable of transforming this interaction measurement into a quantitative information for the user.<\/p><p style=\"font-weight: 400;\"><a href=\"https:\/\/grapheal.com\/#section-industry\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-4917\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/logo-grapheal-300x134.png\" alt=\"\" width=\"119\" height=\"53\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/logo-grapheal-300x134.png 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/logo-grapheal-18x8.png 18w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/logo-grapheal.png 543w\" sizes=\"(max-width: 119px) 100vw, 119px\" \/><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-71f32a1 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"71f32a1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b348b10 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"b348b10\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-1050912 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"1050912\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e475e3b elementor-widget elementor-widget-heading\" data-id=\"e475e3b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Colorimetric aptasensors \u2013 NOVAswitches\n\n<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1b2fc55 elementor-widget elementor-widget-text-editor\" data-id=\"1b2fc55\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400;\">Gold nanoparticles (AuNPs) have the unique ability to change color depending on their aggregation or dispersion state due to the plasmon resonance property of colloidal gold. Novaptech has exploited this property to design NOVAswitch aptasensors. Two batches of AuNPs are functionalized: one with the aptamer and the other with a short oligonucleotide complementary to part of the aptamer. Duplex formation leads to AuNPs aggregation, resulting in a blue-colored solution. When the target molecule binds to the aptamer, it induces a structural change that disrupts the duplex, causing the GNP aggregates to dissociate and shifting the color to red.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb401c2 elementor-widget__width-initial elementor-widget elementor-widget-image-gallery\" data-id=\"eb401c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-5' class='gallery galleryid-4864 gallery-columns-1 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"333\" height=\"204\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/colorimetric-aptasensors.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/colorimetric-aptasensors.png 333w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/colorimetric-aptasensors-300x184.png 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/colorimetric-aptasensors-18x12.png 18w\" sizes=\"(max-width: 333px) 100vw, 333px\" \/>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6ca5e14 elementor-widget elementor-widget-text-editor\" data-id=\"6ca5e14\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400; text-align: center;\"><em>Illustration of a gold nanoparticles-based aptasensor<\/em><\/p><div><span lang=\"EN-US\">Novaptech has designed AuNP-based aptasensors for the detection of fungicides<\/span>. The example below shows a typical assay for the specific and quantitative detection of thiabendazole (TBZ) using a AuNP-based NOVAswitch sensor.<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c7804ec e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"c7804ec\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dbb7b16 elementor-widget__width-initial elementor-widget elementor-widget-image-gallery\" data-id=\"dbb7b16\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-6' class='gallery galleryid-4864 gallery-columns-1 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"469\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/colorimetric-apta-TBZ-1024x600.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/colorimetric-apta-TBZ-1024x600.png 1024w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/colorimetric-apta-TBZ-300x176.png 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/colorimetric-apta-TBZ-768x450.png 768w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/colorimetric-apta-TBZ-1536x900.png 1536w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/colorimetric-apta-TBZ-18x12.png 18w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/colorimetric-apta-TBZ.png 1745w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1af2cbc elementor-widget elementor-widget-text-editor\" data-id=\"1af2cbc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div style=\"text-align: center;\"><p style=\"font-weight: 400;\"><em>Colorimetric detection of TBZ. Upon TBZ binding to its cognate NOVAswitch aptamer immobilized on AuNPs, the absorption peak of AuNPs shifts to a lower wavelength. <\/em><\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f5f78d7 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"f5f78d7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-ab9b16d e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"ab9b16d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-d2824b6 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"d2824b6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-da615b3 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"da615b3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b8c43c elementor-widget elementor-widget-heading\" data-id=\"7b8c43c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Point of care\/ in the field NOVAswitch aptasensors\n\n<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fbc7847 elementor-widget elementor-widget-text-editor\" data-id=\"fbc7847\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-weight: 400;\">Rapid, simple, accurate, and cost-effective tests are valuable for various applications in health, agri-food, and environmental sectors. To this end, Novaptech, in collaboration with <a href=\"https:\/\/www.goyalab.com\/fr\/\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #923393;\">Goyalab<\/span><\/a> , has developed IndiGo, a light, user-friendly, handheld and smartphone-connected spectrophotometer for absorption and emission measurements. It is fully compatible with NOVAswitch.<\/p><p><a href=\"https:\/\/www.goyalab.com\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-4918\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/logo-goyalab-2x-300x110.png\" alt=\"\" width=\"123\" height=\"45\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/logo-goyalab-2x-300x110.png 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/logo-goyalab-2x-18x7.png 18w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/logo-goyalab-2x.png 600w\" sizes=\"(max-width: 123px) 100vw, 123px\" \/><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-92bb835 elementor-widget__width-initial elementor-widget elementor-widget-image-gallery\" data-id=\"92bb835\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-7' class='gallery galleryid-4864 gallery-columns-1 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"284\" src=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/goyalab.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/goyalab.png 945w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/goyalab-300x106.png 300w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/goyalab-768x272.png 768w, https:\/\/novaptech.com\/wp-content\/uploads\/2025\/03\/goyalab-18x6.png 18w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Sensitive detection of analytes with NOVAswitch aptasensors (aptamer-based biosensors). Aptamers are chemically synthesized oligonucleotides. They can be easily conjugated to various functional groups for grafting, immobilization or signaling. This includes (but is not restricted to) amino -NH2, carboxyl -COOH or thiol -SH functions, fluorescent (FAM, Alexa, Cyanine) or redox (methylene blue) reporters. A spacer can be introduced between these groups and either the 5\u2019 or 3\u2019 end of the aptamer. Through our privileged partner, Eurogentec , our customers have full access to such functionally modified aptamers. Aptamers are easily integrated into biosensors, utilizing different signal transduction modalities. At Novaptech, we routinely use Surface Plasmon Resonance (SPR) and Bio-Layer Interferometry (BLI) to characterize aptamer binding (see Novaptech Custom aptamer selection &amp; characterization process). Additionally, Novaptech engineers aptamer-based fluorescent and colorimetric aptasensors for the detection of small molecules and proteins. Our NOVAswitches simplify the design of aptasensors. The structural change induced by the binding of the target to its cognate aptamer is exploited for the emission of a signal. Therefore, our NOVAswitch aptasensors ensure the specific and quantitative detection of the molecule of interest. NOVAswitch in its free form (left) and bound to its target (right). \u00a0 Novaptech can engineer an aptasensor from your own aptamer. Please, contact us! \u00a0 Fluorescent NOVAswitch Aptasensors Fluorescence can be used in several ways in NOVAswitch aptasensors: Molecular beacons Energy transfer Fluorescence anisotropy Molecular beacon \u2013 Structure switching aptamers NOVAswitch A bi-molecular beacon is a combination of a fluorescently labeled aptamer and a short complementary oligonucleotide conjugated to a quencher. The close proximity between the fluorophore and the quencher inhibits the emission of light. When the target molecule binds to the aptamer, it induces a structural change of the NOVAswitch and releases the quenching oligonucleotide, resulting in fluorescence emission that correlates with the target molecule concentration. Scheme of a molecular beacon assay Novaptech has designed molecular beacon-based aptasensors for the detection of various antibiotics .The example below shows a typical assay for the specific detection of streptomycine by a beacon made of a FAM-conjugated NOVAswitch combined with a BHQ1-conjugated complementary oligonucleotide. Fluorescence intensity as a function of antibiotic concentration, demonstrating the specific detection of streptomycin using a molecular beacon-based NOVAswitch aptasensor.\u00a0 Energy transfer with Lanthanide nanoparticles &#8211; Structure switching aptamers NOVAswitch Lanthanide (La) nanoparticles (NPs) are characterized by bright, long-lived fluorescence emission. This fluorescence is quenched when energy is transferred to a dye. In collaboration with Poly-DTech , we designed a NOVAswitch-based aptasensor that combines La particles grafted with a short oligonucleotide complementary to part of an aptamer, which is conjugated to a dye. The binding of the target molecule to the aptamer induces a structural change of the NOVAswitch and dissociates the oligonucleotide hybrid, thereby preventing energy transfer from the nanoparticle to the acceptor, hence allowing the fluorescence emission of the La particle. Scheme of La-NP-based NOVAswitch aptasensor Novaptech has developed La-nanoparticle-based aptasensors for the detection of various fungicides. The example below shows a typical assay for the specific and quantitative detection of thiabendazole (TBZ) using a sensor that includes a dye-conjugated NOVAswitch. La NP-NOVAswitch aptasensors, which enable the measurement of delayed fluorescence, are particularly useful for the quantitative detection of analytes in complex matrices with high fluorescence backgrounds. FRET response as a function of thiabendazole (TBZ) concentration, using La NP-based NOVAswitch aptasensors Fluorescence anisotropy-based aptasensor &#8211; Structure switching aptamers NOVAswitch In this particular format we take advantage of the change in the molecular weight, i.e. the mobility that accompanies the conformational modification of the NOVAswitch in response to the binding to its target. An improved design of the kissing complex-based aptasensor for the detection of adenosine \u00a0 \u00a0 Goux, E., Lisi, S., Ravelet, C., Durand, G., Fiore, E., Dausse, E., Toulm\u00e9, J. J., &amp; Peyrin, E.\u00a0 Keywords: aptamer biosensing, dual recognition, nucleic acid assembly, aptaswitch, loop-loop interactions, kissing complex, fluorescence anisotropy, adenosine-adenoswitch, fluorophore-labeled aptakiss, blocking DNA, detection limit, human serum, biosensor optimization. Electronic conduction (BIOFET) NOVAswitch aptasensors Novaptech, in collaboration with Grapheal is developing a BIOFET-based NOVAswitch sensor for the detection of biomolecules of interest in health sciences. Grapheal is a French spin-off from CNRS-Grenoble which markets a new sensitive material, graphene on polymer, capable of measuring variations in electronic conduction (BIOFET principle). It has developed \u201cGraphLAB\u201d a chemical and biological field analytical sensor capable of transforming this interaction measurement into a quantitative information for the user. Colorimetric aptasensors \u2013 NOVAswitches Gold nanoparticles (AuNPs) have the unique ability to change color depending on their aggregation or dispersion state due to the plasmon resonance property of colloidal gold. Novaptech has exploited this property to design NOVAswitch aptasensors. Two batches of AuNPs are functionalized: one with the aptamer and the other with a short oligonucleotide complementary to part of the aptamer. Duplex formation leads to AuNPs aggregation, resulting in a blue-colored solution. When the target molecule binds to the aptamer, it induces a structural change that disrupts the duplex, causing the GNP aggregates to dissociate and shifting the color to red. Illustration of a gold nanoparticles-based aptasensor Novaptech has designed AuNP-based aptasensors for the detection of fungicides. The example below shows a typical assay for the specific and quantitative detection of thiabendazole (TBZ) using a AuNP-based NOVAswitch sensor. Colorimetric detection of TBZ. Upon TBZ binding to its cognate NOVAswitch aptamer immobilized on AuNPs, the absorption peak of AuNPs shifts to a lower wavelength. Point of care\/ in the field NOVAswitch aptasensors Rapid, simple, accurate, and cost-effective tests are valuable for various applications in health, agri-food, and environmental sectors. To this end, Novaptech, in collaboration with Goyalab , has developed IndiGo, a light, user-friendly, handheld and smartphone-connected spectrophotometer for absorption and emission measurements. It is fully compatible with NOVAswitch.<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-4864","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Biosensors - Novaptech<\/title>\n<meta name=\"description\" content=\"Biomarkers, or biological markers, are measurable indicators present in the human body, such as proteins, nucleic acids, hormones or even cells, which reflect a normal physiological or pathological state.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/novaptech.com\/en\/biosensors\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biosensors - 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