Aptamers vs Antibodies
Key advantages of Aptamers over Antibodies
Aptamers are synthetic molecules that can be raised against any kind of target, including toxic or non immunogenic ones. They bind their target with affinity similar or higher than antibodies. They are 10 fold smaller than antibodies and can be chemically-modified at will in a defined and precise way. They can be easily stored and delivered ; they can be reversibly heat-denatured. The sourcing is guaranteed with a high batch to batch reproducibility.
They can be used under non physiological conditions for analytical purposes.
They are non–immunogenic and can be used in vivo.