Selected publications
diverse applications of aptamers

Over the last years Novaptech developed aptamers against a wide range of targets for diverse applications in health and life sciences, cosmetics, agri-food and environmental sciences.

Below is a selection of publications authored by J.-J. Toulmé, Novaptech CSO.

Aptamers - Health and Life Sciences

Aptamer-conjugated gold nanoparticles enable oligonucleotide delivery into muscle stem cells to promote regeneration of dystrophic muscles

 

 

Francesco Millozzi, Paula Milán-Rois, Arghya Sett, Giovanni Delli Carpini, Marco De Bardi, Miguel Gisbert-Garzarán, Martina Sandonà, Ciro Rodríguez-Díaz, Mario Martínez-Mingo, Irene Pardo, Federica Esposito, Maria Teresa Viscomi, Marina Bouché, Ornella Parolini, Valentina Saccone, Jean-Jacques Toulmé, Álvaro Somoza & Daniela Palacios

Keywords: muscle stem cells, Duchenne dystrophy, gold nanoparticles, microRNA-206, regeneration

Ex Vivo and In Vivo Imaging and Biodistribution of Aptamers Targeting the Human Matrix MetalloProtease-9 in Melanomas

 

David Kryza , Frédéric Debordeaux, Laurent Azéma, Aref Hassan, Olivier Paurelle, Jürgen Schulz, Catherine Savona-Baron, Elsa Charignon, Pauline Bonazza, Jacqueline Taleb, Philippe Fernandez, Marc Janier , Jean Jacques Toulmé

Keywords: Matrix Metalloproteinase-9, aptamer, tumor imaging, melanoma, radiolabeled probe, fluorescence, scintigraphy

A malachite green light-up aptasensor for the detection of theophylline

 

Arghya Sett, L. Zara, É. Dausse, J. Toulmé

Keywords: biosensor, aptamer, fluorescence, theophylline, malachite green, aptasensor

A colorimetric nanosensor based on a selective target-responsive aptamer kissing complex

 

Goux, E. Dausse, V. Guieu,   L. Azéma  G. Durand  M. Henry  L. Choisnard   J.-J. Toulmé   C. Raveleta  and  E. Peyrin

Keywords: colorimetric aptasensor, gold nanoparticles, kissing loop, nanoparticle aggregation, small analyte detection

Aptamers - Cosmetics

Study of a G-quadruplex aptamer inhibiting MMP-9 on human keratinocytes and on a 3D reconstructed human skin model

Robin Kurfurst, Olivier Jeanneton, Isabelle Lorthois, Amélie Thépot, Morgan dos Santos
October 2021; IFSCC Conference 2021, Mexico
 

Keywords: Matrix Metalloproteinase-9, aptamer, SELEX, skin aging, extracellular matrix degradation, Matrix Metalloproteinases inhibition, 3D skin model, G quadruplex

Aptamers – Agri-food, environment

Engineering optical aptasensors for the detection of fungicides

Petra Ivaskovic, Amélie Florent, Hubert Debreyne, Jean Jacques Toulmé
Juin 2024; Journées scientifiques du GDR ChemBio 2024, Bordeaux

Keywords: fungicides, agriculture, aptamers, real time, quantitative detection, fluorescence, optical biosensor 

Development of aptasensors for antibiotic monitoring

 
Hubert Debreyne, Petra Ivaskovic, Célia Gutierrez, Pauline Duboeuf, Jean Jacques Toulmé
2024; Internal use
 

Keywords: antibiotics, food safety, aptamers, real time, quantitative detection, fluorescence, optical biosensor 

Aptamers – Biosensors

Design of a dual aptamer-based recognition strategy for human matrix metalloproteinase 9 protein by piezoelectric biosensors

 
Scarano, E. Dausse, F. Crispo, J.-J. Toulmé, M. Minunni
 

Keywords: Matrix Metalloproteinase-9, aptamer biosensor, piezoelectric detection, label-free assay, neuroinflammation, cardiovascular disease, serum biomarker

ELAKCA: Enzyme-Linked Aptamer Kissing Complex Assay as a Small Molecule Sensing Platform

 
Benoit Chovelon, Guillaume Durand, Eric Dausse, Jean-Jacques Toulmé, Patrice Faure, Eric Peyrin, Corinne Ravelet
 

Keywords: aptamer-based assay, colorimetric detection, small molecule sensing, RNA hairpin, biosensor, theophylline, adenosine, diagnostic tool.

Aptamers – Biomaterials, Nanotechnology

Single-molecule observations of RNA-RNA kissing interactions in a DNA nanostructure

 
 
 
Yosuke Takeuchi , Masayuki Endo, Yuki Suzuki, Kumi Hidaka, Guillaume Durand, Eric Dausse, Jean-Jacques Toulmé, Hiroshi Sugiyama
 

Keywords: RNA nanostructures, molecular switch, aptamer, GTP sensing, DNA origami, single-molecule analysis, ligand-responsive interaction

Triggering nucleic acid nanostructure assembly by conditional kissing interactions

Laurent Azéma,  Servane Bonnet-Salomon,  Masayuki Endo,  Yosuke Takeuchi, Guillaume Durand,   Tomoko Emura,   Kumi Hidaka,   Eric Dausse,  Hiroshi Sugiyama, Jean-Jacques Toulmé

Keywords: nucleic acid nanostructures, aptaswitch, structure-switching aptamer, ligand-responsive assembly, oligonucleotide nanorods, adenosine sensing.

 Deciphering Aromatic Oligoamide Foldamer–DNA Interactions

 

Laurence Delaurière, Dr. Zeyuan Dong, Dr. Katta Laxmi-Reddy, Dr. Frédéric Godde, Dr. Jean-Jacques Toulmé, Dr. Ivan Huc

 

Keywords: foldamers, G-quadruplex, selective interactions, helical aromatic amides, diastereoselectivity, cationic side chains

More publications ?

More publications can be found at Pubmed. For additional information please contact us.

Biomarker analysis

Your scientific contact :

Jean-Jacques Toulmé, PhD, CSO

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